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Journal of Renin-Angiotensin-Aldosterone System
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New basic science initiatives with the angiotensin II receptor blocker valsartan

Marc de Gasparo

Novartis Pharma AG, Basel, Switzerland, m.de_gasparo@ bluewin.ch

Angiotensin II (Ang II) plays a key role in the regulation of blood pressure and fluid homeostasis. Valsartan is a highly selective Ang II receptor blocker that specifically and selectively blocks Ang II at the AT1-receptor. In animal models, valsartan has shown positive effects on vasoconstriction, proliferation, remodelling, endothelial function and thrombogenesis, inflammation and atherosclerosis. These data are likely to be confirmed by the results of current clinical trials and valsartan is set to provide improved cardiovascular therapy in the future.

Key Words: AT1-receptor blocker • vasoconstriction • cell proliferation • preclinical data • endothelial dysfunction • cholesterol uptake

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2 suppl, S3-S5 (2000)
DOI: 10.3317/jraas.2000.052
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