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Journal of Renin-Angiotensin-Aldosterone System
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Angiotensin receptor blocker selectivity at the AT1- and AT2-receptors: conceptual and clinical effects

Thomas Unger

Institute of Pharmacology, Universität zu Kiel, Kiel, Germany, th.unger@ pharmakologie

Steffen Sandmann

Institute of Pharmacology, Universität zu Kiel, Kiel, Germany

The advent of specific angiotensin II (Ang II) receptor blockers (ARBs) some ten years ago has provided substantial information on the specific actions of the AT1- and AT2-receptors. Most of the early research concentrated on the AT1-receptor, and the actions and biological roles of the AT2-receptor are much less well characterised. The AT2-receptor is involved in the inhibition of cell proliferation, and in cell differentiation and development, regeneration and apoptosis. By raising local Ang II concentrations at the AT2-receptor, selective blocking of the AT1-receptor may therefore have beneficial effects. This concept may be important for antihypertensive therapy and in cardiovascular disease in general.

Key Words: angiotensin II AT2-receptor • Ang II receptor blocker • myocardial infarction • valsartan • intracellular pH regulation • Na+/H+ exchange

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2 suppl, S6-S9 (2000)
DOI: 10.3317/jraas.2000.057
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