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Journal of Renin-Angiotensin-Aldosterone System
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Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction

Yi Zhun Zhu

Department of Pharmacology, University of Kiel, Germany, Department of Pharmacology, National University of Singapore, Singapore

Yi-Chun Zhu

Department of Pharmacology, University of Kiel, Germany, Department of Physiology, Shanghai Medical University, China

Jun Li

Department of Pharmacology, University of Kiel, Germany

Heiner Schäfer

Department of Internal Medicine, University Hospital of Kiel, Germany

Wolfgang Schmidt

Department of Internal Medicine, University Hospital of Kiel, Germany

Tai Yao

Department of Physiology, Shanghai Medical University, China

Thomas Unger

Department of Pharmacology, University of Kiel, Germany, th.unger@ pharmakologie

We investigated the haemodynamic parameters and the regulation of cardiac mRNA levels of the angiotensin receptor subtypes, AT1 and AT2, by the AT1-receptor antagonist losartan in rat heart during the acute phase of myocardial infarction. AT1- and AT2-receptor mRNA levels markedly increased at 30 minutes and peaked at 24 hours post myocardial infarction (12.6-fold increase for AT1- and 17.2-fold increase for AT2 compared with controls). Losartan significantly reduced mean blood pressure in sham-operated rats and decreased mean blood pressure and left ventricular end-diastolic pressure in myocardial infarction rats. However, the AT1- and AT2-receptor mRNA levels of losartan-treated rats showed a pattern similar to that of water-treated rats. The time-dependent increase of AT 1- and AT2receptor mRNA levels is associated with the early remodelling process of non-infarcted myocardium post MI and is independent of AT1-receptor blockade.

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 3, 257-262 (2000)
DOI: 10.3317/jraas.2000.039
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