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Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population

Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China

Yuan-Ying Gong

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

Liang Xie

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China, Graduate University of the Chinese Academy of Sciences, Beijing, China

Shi-Gang Lian

People's Hospital of Dujiang Weirs City, Dujiang Weirs City, China

Juan Yang

People's Hospital of Dujiang Weirs City, Dujiang Weirs City, China

Liang-You Xu

Dujiangyan Longevity Research Centre, Dujiangyan, China

Shou-Jun Gao

Dujiangyan Longevity Research Centre, Dujiangyan, China

Ya-Ping Zhang

Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China, zhangyp1@263. net.cn, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

Introduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population.

Materials and methods. We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years.

Results. No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884).

Conclusions. No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population.

Key Words: angiotensin-converting enzyme • Han Chinese population • longevity • polymorphism

Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 2, 115-118 (2009)
DOI: 10.1177/1470320309104873


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