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Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile, dbunout{at}inta.cl

Gladys Barrera

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile

María Pía de la Maza

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile

Laura Leiva

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile

Claudia Backhouse

Department of Medicine, Central Campus Faculty of Medicine, University of Chile, Santiago, Chile

Sandra Hirsch

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile

Introduction. The inhibition of angiotensin-converting enzyme could be useful to avoid sarcopenia in the elderly.

Materials and methods. We compared in a prospective double blind trial, the effects of treatment with enalapril or nifedipine on muscle performance in hypertensive elderly subjects. Patients were followed for nine months, and at baseline, 4.5 months and the end of follow-up, quadriceps and hand grip muscle strength, walking capacity, timed up and go and the short physical performance test were measured. Results. During follow-up, more subjects on nifedipine than on enalapril discontinued the medication due to side-effects. No differences in the evolution of muscle strength, walking capacity or functional measures were observed. At nine months, plasma angiotensin-converting enzyme activity decreased by 6.0±2.5 U/L among patients on enalapril and increased by 8.5±4.2 U/L (p<0.001) among patients on nifedipine.

Conclusion. In this group of elderly subjects, enalapril was not superior to nifedipine with regard to the age-related decline of muscle performance.

Key Words: enalapril • muscle strength • nifedipine • sarcopenia

Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 2, 77-84 (2009)
DOI: 10.1177/1470320309105338


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