SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Renin-Angiotensin-Aldosterone System
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ozben, B.
Right arrow Articles by Toprak, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ozben, B.
Right arrow Articles by Toprak, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Perindopril decreases P wave dispersion in patients with stage 1 hypertension

Beste Ozben

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey, bestes{at}doctor.com

Mutlu Sumerkan

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Azra Meryem Tanrikulu

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Nurdan Papila-Topal

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Ali Serdar Fak

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Ahmet Toprak

Department of Internal Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey

Introduction. Angiotensin-converting enzyme inhibitors prevent atrial fibrillation episodes by effective control of blood pressure and improving electrical and structural remodelling in the atria. Increased P wave dispersion (PWD) is a non-invasive electrocardiographic marker for paroxysmal atrial fibrillation. The aim of the study was to evaluate the effect of perindopril treatment on PWD in hypertensive patients. Methods. Forty-eight hypertensive patients (mean age 57.4±11.8 years, 18 men) were included. Blood pressure values were determined and 12-lead electrocardiograms were recorded at the beginning and at the first week, first month, third month and sixth month of the perindopril treatment.The difference between maximum and minimum P wave durations was calculated as PWD.

Results. PWDs were significantly shortened at the first, third and sixth months (41.7±8.8 ms, 39.1±6.9 ms and 38.3±7.1 ms, respectively) compared with baseline and first-week measurements (54.3±9.2 ms and 49.0±9.1 ms, respectively, p<0.001). Baseline PWD was correlated with body mass index (r=0.32, p=0.026), while PWD at the sixth month of treatment was significantly correlated with left atrial volume index (r=0.30, p=0.042). Multiple linear regression analysis revealed that PWD at the sixth month was related to baseline PWD (p=0.001).

Conclusion. Perindopril treatment significantly reduced PWD in hypertensive patients.

Key Words: angiotensin-converting enzyme inhibitor • atrial fibrillation • electrocardiography • hypertension • perindopril • P wave dispersion

Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 2, 85-90 (2009)
DOI: 10.1177/1470320309105199
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement