This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Settin, A. Articles by Noaman, A. Search for Related Content PubMed PubMed Citation Articles by Settin, A. Articles by Noaman, A. Social Bookmarking                         What's this?

Angiotensin-converting enzyme gene insertion/deletion polymorphism in Egyptian patients with myocardial infarction

Department of Genetics, Faculty of Medicine, Mansoura University, Mansoura, Egypt, settin60{at}gmail.com

Rizk ElBaz

Department of Genetics, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Amr Abbas

Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Ayman Abd-Al-Samad

Department of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Ahmed Noaman

Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt

Introduction. This work aimed to test the association of the angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism with myocardial infarction.

Subjects and methods. This study comprised 79 Egyptian myocardial infarction cases with a mean age of 54.4±9.9 years including 60 males and 19 females, plus 238 healthy unrelated individuals of nearly matched age and sex as a control group. For all subjects, DNA testing for the angiotensin-converting enzyme gene I/D polymorphism was done using PCR amplification for detection of both the D and I alleles followed by a second run PCR specific for the I allele for samples typed as DD in the first run.

Results. Cases had a higher frequency of DD (29.1%) and ID (62.0%) genotypes than II (8.9%) genotype, with a higher frequency of D allele than I allele (64.4% vs. 33.6%). Compared to controls, cases had a significantly higher frequency of ID genotype (62.0% vs. 47.5%, p<0.05).This was more apparent among cases in the low risk group (p=0.002) than in the high risk group (p=0.041).

Conclusion. The angiotensin-converting enzyme gene I/D polymorphism is probably a risk factor for ischaemic heart disease among Egyptian cases, particularly if integrated with other environmental and genetic risk factors.

Key Words: angiotensin-converting enzyme • Egypt • gene polymorphism • ischaemic heart disease • myocardial infarction

Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 2, 96-100 (2009)
DOI: 10.1177/1470320309105198


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?