SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Renin-Angiotensin-Aldosterone System
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bhoomi Reddy Pullareddy
Right arrow Articles by Jyothy, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bhoomi Reddy Pullareddy,
Right arrow Articles by Jyothy, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients

Bhoomi Reddy Pullareddy

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Baddela Muni Venkata Srikanth Babu

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Kolla Venkata Karunakar

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Jeedigunta Yasovanthi

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Potham Sampath Kumar

Osmania General Hospital, Afzul Gunj, Hyderabad-500012, India

Annam Sharath

Osmania General Hospital, Afzul Gunj, Hyderabad-500012, India

Akka Jyothy

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India, jyothycell{at}rediffmail.com

Introduction. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients.

Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction.

Results. Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was {chi}2 = 2.08, odds ratio 2.30, 95% confidence interval 0.72 — 7.23, and p value was 0.14.

Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.

Key Words: A1166C polymorphism • angiotensin II type 1 receptor • myocardial infarction • polymerase chain reaction • South Indian population

Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 3, 174-178 (2009)
DOI: 10.1177/1470320309342758
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement