This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Dalmay, F. Articles by Fournier, A. Search for Related Content PubMed PubMed Citation Articles by Dalmay, F. Articles by Fournier, A. Social Bookmarking                   What's this?

Non-AT1-receptor-mediated protective effect of angiotensin against acute ischaemic stroke in the gerbil

Department of Physiology, University Hospital of Limoges, France

Hakim Mazouz

Division of Nephrology, University Hospital of Amiens, France

Julien Allard

Department of Physiology, University Hospital of Limoges, France

Francis Pesteil

Department of Physiology, University Hospital of Limoges, France

Jean Michel Achard

Department of Physiology, University Hospital of Limoges, France

Albert Fournier

Division of Nephrology, University Hospital of Amiens, France, neph{at}chu-amiens.fr

Previous studies have shown that angiotensin II (Ang II), by mediating rapid recruitment of collateral circulation, has a protective effect in the setting of acute ischaemia. In an experimental model of acute cerebral ischaemia in the gerbil, Fernandez et al. have reported that the mechanism of the protective effect of Ang II is blood pressure (BP)-independent,¹ and that the AT ₁-receptor antagonist, losartan, but not the ACE inhibitor (ACE-I), enalapril, decreases mortality following unilateral carotid artery ligation. ² The aim of this study was to examine the reproducibility of the respective effects of losartan and enalapril, and to verify that these differential effects are drug class-related. Acute cerebral ischaemia was induced in anaesthetised gerbils by unilateral carotid ligation. The effect of pretreatment with two different ACE-I (enalapril and lisinopril), and two different AT ₁-receptor antagonists (losartan and candesartan), administered orally or intravenously, on mortality were compared. Kaplan-Meier survival curves at day three were analysed by a log-rank test. Pretreatment with both enalapril and lisinopril significantly decreased survival at day three compared with controls, while the AT₁-receptor antagonists losartan and candesartan, despite similarly lowering BP, did not increase mortality. Coadministration of losartan and enalapril increased mortality to the same extent as enalapril alone. This study confirms that Ang II contributes to protective mechanisms against acute cerebral ischaemia through non AT₁-receptor-mediated, BP-independent effects.

Key Words: AT1-receptor • stroke

Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 2, 103-106 (2001)
DOI: 10.3317/jraas.2001.009


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Kobayashi, N. Hirawa, K. Yatsu, Y. Kobayashi, Y. Yamamoto, S. Saka, D. Andoh, Y. Toya, G. Yasuda, and S. Umemura Relationship between silent brain infarction and chronic kidney disease Nephrol. Dial. Transplant., January 1, 2009; 24(1): 201 - 207. [Abstract] [Full Text] [PDF]

				D. N. Granger, T. Vowinkel, and T. Petnehazy Modulation of the Inflammatory Response in Cardiovascular Disease Hypertension, May 1, 2004; 43(5): 924 - 931. [Abstract] [Full Text] [PDF]

				A. Fournier, F. H. Messerli, J. M. Achard, and L. Fernandez Cerebroprotection mediated by angiotensin II: A hypothesis supported by recent randomized clinical trials J. Am. Coll. Cardiol., April 21, 2004; 43(8): 1343 - 1347. [Abstract] [Full Text] [PDF]