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Journal of Renin-Angiotensin-Aldosterone System
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Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment

Jean Doucet

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France, jean.doucet{at}chu-rouen.fr

Vincent Richard

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France

Paul Mulder

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France

Jean-Paul Henry

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France

Pierre Schiavi

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France

David Guez

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France

Christian Thuillez

Department of Pharmacology (VACOMED, IFRMP 23), Rouen University Medical School, Rouen, France

The goal of this study was to assess the effect of acute or chronic treatment with S5590, a combination of the angiotensin-converting enzyme inhibitor perindopril (0.76 mg/kg/day) and the diuretic indapamide (0.24 mg/kg/day) on renal function in spontaneously hypertensive rats with moderate renal injury.

Renal function was evaluated in conscious rats by clearance methods using labelled inulin and PAH, after catheterisation of the carotid artery, jugular vein and bladder.

Both acute and chronic treatment normalised renal vascular resistance, although the effect on blood pressure was more marked after chronic than after acute treatment. Although acute treatment with S5590 increased glomerular filtration rate and renal blood flow, chronic treatment did not affect these parameters. Diuresis and natriuresis were only slightly modified and the results suggest a marked renal vasodilatation.

In conclusion, the maintenance of renal function after chronic treatment, in a setting of normalisation of arterial pressure, suggest that such a combined treatment may exert marked renal functional protective effects in hypertension.

Key Words: renal function • angiotensin-converting enzyme inhibitor • diuretics • spontaneously hypertensive rats

Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 2, 107-111 (2001)
DOI: 10.3317/jraas.2001.010
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