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Journal of Renin-Angiotensin-Aldosterone System
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*Kidney Transplantation
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Renal graft failure after addition of an angiotensin II receptor antagonist to an angiotensin-converting enzyme inhibitor: unmasking of an unknown iliac artery stenosis

Anne-Lise Kamper

Department of Nephrology, Herlev Hospital, ankam@ herlevhosp.kbhamt.dk

Arne Høj Nielsen

Department of Nephrology, Herlev Hospital

Niels Bækgaard

Department of Vascular Surgery, University of Copenhagen

Svend Just

Department of Radiology, Gentofte Hospital, University of Copenhagen, Denmark

Combined treatment with an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II (Ang II) receptor blocker (ARB) has been suggested in order to achieve a more complete blockade of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. The present report describes a case of acute renal graft dysfunction following the addition of an ARB to existing ACE inhibition. This unmasked an unknown iliac artery stenosis. The case indicates a possible important role of Ang II generated by non-ACE pathways in this situation.

Key Words: dual angiotensin II blockade • renal artery stenosis • renal graft dysfunction

Journal of Renin-Angiotensin-Aldosterone System, Vol. 3, No. 2, 135-137 (2002)
DOI: 10.3317/jraas.2002.016
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