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Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production

MRC Blood Pressure Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G11 6NT, Scotland, 9244731m@ clinmed.gla.ac.uk

Robert Fraser

MRC Blood Pressure Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G11 6NT, Scotland

John MC Connell

MRC Blood Pressure Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G11 6NT, Scotland

Eleanor Davies

MRC Blood Pressure Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G11 6NT, Scotland

Adrenal aldosterone production is regulated by the renin-angiotensin system (RAS). It is now known that several other tissues are capable of extra-adrenal aldosterone biosynthesis and that these tissues can also generate angiotensin II through local RAS. Therefore, the regulation of local aldosterone production by the local RAS is a distinct possibility. In this review, we present evidence for the existence of such systems in the vascular system, heart and brain. We then discuss the possibility of interactions between the RAS and aldosterone synthesis at the local level and speculate on the possible physiological effects of such systems in these tissues.

Key Words: aldosterone synthase • 11beta-hydroxylase • mineralocorticoids • glucocorticoids • heart • brain • vascular system

Journal of Renin-Angiotensin-Aldosterone System, Vol. 3, No. 4, 214-221 (2002)
DOI: 10.3317/jraas.2002.043


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