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The Pickering Lecture British Hypertension Society, 10th September 2002Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease
David G Harrison
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA, dharr02{at}emory.edu
Hua Cai
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA
Ulf Landmesser
Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Kathy K Griendling
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA
An elevation in angiotensin II (Ang II) levels is a common occurrence in a diverse number of cardiovascular diseases including hypertension, hypercholesterolaemia, atherosclerotic coronary artery disease, left ventricular hypertrophy (LVH), heart failure and diabetes. An important effect of Ang II is activation of the NAD(P)H oxidase, a major source of reactive oxygen species (ROS) production by vascular cells. This increase in cellular ROS contributes to the pathogenesis of vascular disease by altering endothelial cell function, enhancing smooth muscle cell growth and proliferation, stimulating inflammatory proteins, including macrophage chemoattractant agents, growth factors and cytokines, and modulating matrix remodelling. Studies of genetically-altered mice have unequivocally shown that activation of the NAD(P)H oxidase by Ang II contributes to hypertension, LVH and atherosclerosis. Furthermore, increasing evidence suggest that the NAD(P)H oxidase contributes to human disease, suggesting that it is a potential target for future therapeutic intervention.
Key Words: angiotensin II • reactive oxygen species • vascular disease • NAD(P)H oxidase
Journal of Renin-Angiotensin-Aldosterone System, Vol. 4, No. 2,
51-61 (2003)
DOI: 10.3317/jraas.2003.014
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121(4):
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29(5):
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53(5):
767 - 774.
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|
|
|
|
|
|
|
R. Zhang, P. Harding, J. L. Garvin, R. Juncos, E. Peterson, L. A. Juncos, and R. Liu
Isoforms and Functions of NAD(P)H Oxidase at the Macula Densa
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53(3):
556 - 563.
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|
|
|
|
|
|
|
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November 1, 2008;
295(5):
G1131 - G1137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Monassier, M.-A. Laplante, F. Jaffre, P. Bousquet, L. Maroteaux, and J. de Champlain
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52(2):
301 - 307.
[Abstract]
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[PDF]
|
|
|
|
|
|
|
J. M. Stewart, I. Taneja, N. Raghunath, D. Clarke, and M. S. Medow
Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response
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July 1, 2008;
295(1):
H327 - H334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome
Am J Physiol Heart Circ Physiol,
January 1, 2008;
294(1):
H466 - H473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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October 1, 2007;
293(4):
H2009 - H2023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Whaley-Connell, G. Govindarajan, J. Habibi, M. R. Hayden, S. A. Cooper, Y. Wei, L. Ma, M. Qazi, D. Link, P. R. Karuparthi, et al.
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293(1):
E355 - E363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Nouri, P. Gill, M. Li, C. S. Wilcox, and W. J. Welch
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April 1, 2007;
292(4):
H1685 - H1689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Just, A. J. M. Olson, C. L. Whitten, and W. J. Arendshorst
Superoxide mediates acute renal vasoconstriction produced by angiotensin II and catecholamines by a mechanism independent of nitric oxide
Am J Physiol Heart Circ Physiol,
January 1, 2007;
292(1):
H83 - H92.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Chen and J. L. Mehta
Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone
Am J Physiol Heart Circ Physiol,
October 1, 2006;
291(4):
H1738 - H1745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-D. Lee, C.-H. Chu, E.-J. Huang, M.-C. Lu, J.-Y. Liu, C.-J. Liu, H.-H. Hsu, J. A. Lin, W.-W. Kuo, and C.-Y. Huang
Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation.
Am J Physiol Endocrinol Metab,
August 1, 2006;
291(2):
E306 - E314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zhao, R. A. Ahokas, K. T. Weber, and Y. Sun
ANG II-induced cardiac molecular and cellular events: role of aldosterone
Am J Physiol Heart Circ Physiol,
July 1, 2006;
291(1):
H336 - H343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Stump, M. T. Hamilton, and J. R. Sowers
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June 1, 2006;
81(6):
796 - 806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-Y. Yi, V. X. Li, F. Zhang, F. Yi, D. R. Matson, M. T. Jiang, and P.-L. Li
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290(3):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Wilcox
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289(4):
R913 - R935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Shimoni, D Hunt, M Chuang, K. Y Chen, G Kargacin, and D. L Severson
Modulation of potassium currents by angiotensin and oxidative stress in cardiac cells from the diabetic rat
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567(1):
177 - 190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chalupsky and H. Cai
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June 21, 2005;
102(25):
9056 - 9061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Bernstein, H. D. Xiao, J. W. Adams, K. Frenzel, P. Li, X. Z. Shen, J. M. Cole, and S. Fuchs
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J. Am. Soc. Nephrol.,
March 1, 2005;
16(3):
583 - 591.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Lu, B. G. Helwig, R. J. Fels, S. Parimi, and M. J. Kenney
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Am J Physiol Heart Circ Physiol,
December 1, 2004;
287(6):
H2626 - H2633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Wassmann, T. Czech, M. van Eickels, I. Fleming, M. Bohm, and G. Nickenig
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November 9, 2004;
110(19):
3062 - 3067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chen, J. Chen, D. Li, X. Zhang, and J. L. Mehta
Angiotensin II Regulation of Collagen Type I Expression in Cardiac Fibroblasts: Modulation by PPAR-{gamma} Ligand Pioglitazone
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November 1, 2004;
44(5):
655 - 661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Fink, K. Laude, L. McCann, A. Doughan, D. G. Harrison, and S. Dikalov
Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay
Am J Physiol Cell Physiol,
October 1, 2004;
287(4):
C895 - C902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Kawada, K. Dennehy, G. Solis, P. Modlinger, R. Hamel, J. T. Kawada, S. Aslam, T. Moriyama, E. Imai, W. J. Welch, et al.
TP receptors regulate renal hemodynamics during angiotensin II slow pressor response
Am J Physiol Renal Physiol,
October 1, 2004;
287(4):
F753 - F759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Zimmerman, E. Lazartigues, R. V. Sharma, and R. L. Davisson
Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System
Circ. Res.,
July 23, 2004;
95(2):
210 - 216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M Ridker, N. J. Brown, D. E. Vaughan, D. G. Harrison, and J. L. Mehta
Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events
Circulation,
June 29, 2004;
109(25_suppl_1):
IV-6 - IV-19.
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Li, H. Rayford, and B. D. Uhal
Essential Roles for Angiotensin Receptor AT1a in Bleomycin-Induced Apoptosis and Lung Fibrosis in Mice
Am. J. Pathol.,
December 1, 2003;
163(6):
2523 - 2530.
[Abstract]
[Full Text]
|
|
|
|
|
