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Journal of Renin-Angiotensin-Aldosterone System
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Aldosterone and cardiovascular remodelling: focus on myocardial failure

Frederick K Shieh

Boston University Medical School Boston, MA, USA

Eugene Kotlyar

Division of Cardiology, Department of Medicine Boston University Medical Center, Boston, MA, USA

Flora Sam

Boston University Medical School Boston, MA, USA, flora.sam{at}bmc.org, Division of Cardiology, Department of Medicine Boston University Medical Center, Boston, MA, USA

Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.

Key Words: aldosterone • heart failure • myocardial • vascular • remodelling

Journal of Renin-Angiotensin-Aldosterone System, Vol. 5, No. 1, 3-13 (2004)
DOI: 10.3317/jraas.2004.005
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[Abstract] [Full Text] [PDF]


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