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A rare combination consisting of aldosterone-producing adenoma and adrenal myelolipoma in a patient with heterozygosity for retinoblastoma (RB) gene

Department of Clinical Science, University of Rome 'La Sapienza'

Giorgio De Toma

Surgery 'P. Valdoni', University of Rome 'La Sapienza'

Alfredo Bossini

Department of Clinical Science, University of Rome 'La Sapienza'

Rosario Cianci

Department of Clinical Science, University of Rome 'La Sapienza'

Cesare Bosman

Experimental Medicine and Pathology, University of Rome 'La Sapienza'

Maurizio Genuardi

Institute of Genetics, University of Florence, Italy

Sabrina Cerci

Department of Clinical Science, University of Rome 'La Sapienza'

Claudio Letizia

Department of Clinical Science, University of Rome 'La Sapienza', claudio.letizia{at}uniroma1.it

Various pathological disorders have been associated with primary aldosteronism, including glucagonoma, phaeochromocytoma and primary hyperparathyroidism.

In this report, a case of adrenal myelolipoma (a rare non-functioning tumour composed of mature adipose tissue and normal haematopoietic elements similar to bone marrow cells), aldosterone-producing adenoma and a pituitary microadenoma coexisting in a 62-year-old man with a 15-year history of arterial hypertension, previous ablation of an autonomously-functioning thyroid adenoma, multiple lipomas and an heterozygosity of the retinoblastoma (RB) susceptibility gene is reported.

We believe that this case probably represents another variant of the multiple neoplasia syndrome and we speculate that structural alteration of the RB gene may play a role in the tumorogenesis.

Key Words: aldosterone-producing adenoma • adrenal myelolipoma • multiple lipomas • retinoblastoma gene (RB)

Journal of Renin-Angiotensin-Aldosterone System, Vol. 5, No. 1, 45-48 (2004)
DOI: 10.3317/jraas.2004.008


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