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Journal of Renin-Angiotensin-Aldosterone System
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Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries

Ion Haulica

Laboratory of Experimental and Applied Physiology of the Romanian Academy, Romania, ihaulica{at}yahoo.com

Walther Bild

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Christian Mihaila

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Dragomir N Serban

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Lacramioara Serban

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Daniela Boisteanu

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Teodor Ionita

Laboratory of Experimental and Applied Physiology of the Romanian Academy, Romania

Oana Radasanu

Laboratory of Experimental and Applied Physiology of the Romanian Academy, Romania

Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system.

The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor).

Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones.

Key Words: adrenomedullin • angiotensin II • L-NAME • methylene blue • guanylate cyclase

Journal of Renin-Angiotensin-Aldosterone System, Vol. 5, No. 2, 79-83 (2004)
DOI: 10.3317/jraas.2004.014
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