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Journal of Renin-Angiotensin-Aldosterone System
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Regulation of renal proximal fluid uptake by luminal and peritubular angiotensin II

Siriphun Hiranyachattada

Department of Physiology, Faculty of Science, Prince of Songkla University, Hatyai, Songkla 90112, Thailand, hsiriphu{at}ratree.psu.ac.th

Peter J Harris

Department of Physiology, The University of Melbourne, Victoria 3010, Australia

Introduction

Angiotensin II (Ang II), when administered to either tubular lumen or peritubular capillary, exerts a biphasic action on proximal fluid uptake rate. At low concentrations, (10-12—10-10M) Ang II stimulates fluid transport, whereas higher doses (> 10-9 M) inhibit. Ang II is secreted into the lumen in the proximal tubule and the concentration of Ang II in the proximal lumen has been reported to be in the nanomolar range, 100—1,000 times higher than in peritubular blood. We investigated the regulation of renal proximal fluid transport by luminal (predominantly locally produced) and peritubular capillary (circulatory) Ang II in anaesthetised rats, using a selective AT1-receptor antagonist, candesartan.

Key Words: Angiotensin II • candesartan • fluid transport • proximal tubule • split-droplet micropuncture

Journal of Renin-Angiotensin-Aldosterone System, Vol. 5, No. 2, 89-92 (2004)
DOI: 10.3317/jraas.2004.016
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