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Review: Arterial stiffness and the renin-angiotensin-aldosterone systemDepartment of Pharmacology and Therapeutics, Trinity Centre for Health Sciences and Hypertension Clinic, St. James's Hospital, Dublin 8, Ireland, mahmuda{at}tcd.ie
Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences and Hypertension Clinic, St. James's Hospital, Dublin 8, Ireland Arterial stiffness has recently been recognised as an independent risk factor for cardiovascular morbidity and mortality in hypertension. Many of the complications seen with angiotensin II (Ang II) excess or hyperaldosteronism — an increased event rate, left ventricular hypertrophy, endothelial dysfunction and target organ damage — are also associated with arterial stiffness. It is possible that reduced arterial compliance may be one mechanism whereby increased activity of the renin-angiotensin-aldosterone system (RAAS) produces adverse vascular effects. Common pathophysiological processes, altered collagen turnover and increased fibrosis may underlie both arterial stiffness and RAAS-associated vascular damage. While it is recognised that patients with hyperaldosteronism have increased arterial stiffness, the role of the RAAS in modulating arterial compliance in essential hypertension and in normotensive subjects is less clear cut. There is, however, more consistent data which show that drugs that interfere with Ang II or aldosterone, namely angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and aldosterone antagonists, all reduce arterial stiffness. In many cases, this is to a greater extent than predicted from the extent of reduction in blood pressure (BP), suggesting a role for RAAS in vascular stiffness in hypertensive subjects. There is also evidence that combined ACE inhibitors (ACE-Is) and ARBs may have an additive effect in reducing stiffness. The reduction in cardiovascular mortality in end-stage renal disease patients treated with ACE-Is was preferentially seen in those who had reduced arterial stiffness. These data suggest that, in addition to regulation of vascular biology and BP, the RAAS is an important determinant of arterial stiffness in health and, more particularly, in disease.
Key Words: blood pressure • renin-angiotensin-aldosterone system • wave reflection • arterial stiffness
Journal of Renin-Angiotensin-Aldosterone System, Vol. 5, No. 3,
102-108 (2004) This article has been cited by other articles:
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