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Journal of Renin-Angiotensin-Aldosterone System
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Are Multiple Angiotensin Receptor Types Involved in Angiotensin (1-7) Actions on Isolated Rat Portal Vein?

Bogdan Gurzu

Department of Physiology, Faculty of Medicine

Marcel Costuleanu

Department of Physiopathology, Faculty of Dentistry, University of Medicine and Pharmacy Iasi, Romania

Simona Mihaela Slatineanu

Department of Physiology, Faculty of Medicine

Aurica Ciobanu

Department of Physiology, Faculty of Medicine

Gheorghe Petrescu

Department of Physiology, Faculty of Medicine, petrescugh{at}yahoo.com

Angiotensin (1-7) [Ang (1-7)] is a bioactive component of the renin angiotensin system. Ang (1-7) may interact with angiotensin type 1 (AT1) or type 2 (AT2) receptors and with Ang (1-7) — specific receptors. We examined the interactions between different doses of Ang (1-7) (1nM-1microM) and angiotensin II (Ang II) (10 and 100nM) on isolated rat portal vein. In endothelium-denuded portal vein rings, Ang (1-7) inhibited contractile effects induced by Ang II. The effects of Ang (1-7) were modified by indomethacin, N(G)-nitro-L-arginine methyl ester (L-NAME), (D-Ala7)-Angiotensin (1-7) (H-2888) and losartan. Our results suggest that on rat isolated portal vein rings without endothelium, Ang (1-7) reduces Ang II—induced contractions by acting mostly on Ang (1-7) specific receptors, and this effect is mediated by vasodilatatory prostaglandins. At high concentrations, Ang (1-7) effects are mediated by AT1-receptors, though to a lesser extent than by Ang (1-7) specific receptors.

Key Words: Angiotensin (1-7) • Angiotensin II • Indomethacin • L-NAME • Portal vein • Rat

Journal of Renin-Angiotensin-Aldosterone System, Vol. 6, No. 2, 90-95 (2005)
DOI: 10.3317/jraas.2005.015
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