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Journal of Renin-Angiotensin-Aldosterone System
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Renin-angiotensin system expression in the K562 human erythroleukaemic cell line

Ebru Koca

Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey, ebrukoca{at}gmail.com

Ibrahim C Haznedaroglu

Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey

Kadir Acar

Gazi University Medical School, Department of Haematology, Ankara, Turkey

Yavuz Beyazit

Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey

Salih Aksu

Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey

Muge Misirlioglu

Metis Biotechnology, Inc., Ankara, Turkey

Serdar Tuncer

Metis Biotechnology, Inc., Ankara, Turkey

Nilgun Sayinalp

Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey

Osman I Ozcebe

Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey

Aysegul Uner

Hacettepe University Medical School, Department of Pathology, Ankara, Turkey

Local renin-angiotensin system (RAS) may affect leukaemic cell production within the bone marrow microenvironment.Angiotensin-converting enzyme (ACE), renin, and angiotensin could influence leukaemogenesis. In this study, mRNA expressions of the major RAS components (ACE, renin, and angiotensinogen) in K562 human erythroleukaemia cell line have been searched by Real Time quantitative polymerase chain reaction. K562 blasts are multipotential, haematopoietic malignant cells that spontaneously differentiate into recognisable progenitors of the erythrocyte, granulocyte and monocytic series.We observed significant expressions of ACE, renin, and angiotensinogen in K562 leukaemic blast cells.Therefore, K562 human erythroleukaemia cell line may serve as an in vitro model to elucidate the role of RAS in leukaemia and to test the effects of RAS-affecting drugs on leukaemic cellular proliferation.

Key Words: renin-angiotensin system • ACE • renin • angiotensinogen • cell line • K562 human erythroleukaemia

Journal of Renin-Angiotensin-Aldosterone System, Vol. 8, No. 3, 145-147 (2007)
DOI: 10.3317/jraas.2007.019
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