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Plasma matrix metalloproteinase-9 and ACE-inhibitor-induced improvement of urinary albumin excretion in non-diabetic, microalbuminuric subjects

St Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands

Pim van der Harst

University Medical Center Groningen, University of Groningen, Department of Cardiology, Hanzeplein 1, 9700 RB, Groningen, The Netherlands, University Medical Center Groningen, University of Groningen, Department of Experimental Cardiology, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands

Wim BM Gerritsen

St Antonius Hospital, Department of Clinical Chemistry, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands

Fal van der Horst

St Antonius Hospital, Department of Clinical Chemistry, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands

Thijs HW Plokker

St Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands

Ron T Gansevoort

University Medical Center Groningen, University of Groningen, Department of Internal Medicine, Hanzeplein 1, 9700 RB, Groningen, The Netherlands

Wiek H van Gilst

University Medical Center Groningen, University of Groningen, Department of Experimental Cardiology, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands

Adriaan A Voors

University Medical Center Groningen, University of Groningen, Department of Cardiology, Hanzeplein 1, 9700 RB, Groningen, The Netherlands, a.a.voors{at}thorax.umcg.nl

Introduction. Elevated plasma matrix metalloproteinase-9 (MMP-9) levels have been suggested to precede the development of microalbuminuria. As angiotensin-converting enzyme (ACE) inhibitors effectively reduce urinary albumin excretion (UAE), in the present study we have investigated the potential association of plasma MMP-9 levels with UAE and treatment effects of ACE-inhibition. Material and methods. In a placebo-controlled

randomised trial we determined plasma MMP-9 levels at baseline and after three months of randomisation to either placebo (n=202) or fosinopril (20 mg/day, n=204) treatment.

Results. Baseline plasma MMP-9 levels were not related to baseline UAE (r=-0.008, p=0.871).Three months of fosinopril treatment effectively reduced UAE compared to placebo treatment (-10.4±2.4 vs. 1.8±1.3 mg/24 hours, p<0.001, respectively). However, fosinopril treatment failed to significantly change plasma MMP-9 levels compared to placebo (-0.47±7.68 vs. 0.06±9.20, p=0.646, respectively) . In addition, the change in UAE was not related with change in MMP-9 levels.

Conclusion. The effective reduction of UAE with fosinopril was not related to plasma MMP-9 levels.

Key Words: angiotensin-converting enzyme • ACE-inhibitors • fosinopril matrix metalloproteinase-9 • urinary albumin excretion

Journal of Renin-Angiotensin-Aldosterone System, Vol. 8, No. 4, 177-180 (2007)
DOI: 10.3317/jraas.2007.029


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