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Insights derived from ACE knockout mice
Justin Cole
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
Dilek Ertoy
Hacettepe University, Ankara, Turkey
Kenneth E Bernstein
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA, kbernst@ emory.edu
Key Words: knockout mice angiotensin converting enzyme angiotensin II renal development blood pressure
References
- Capecchi MR Targeted gene replacement. Scientific American 1994; 270; 52-9.[Web of Science][Medline]
[Order article via Infotrieve]
- Kim HS, Krege JH, Kluckman KD et al. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 1995;92; 2735-9.[Abstract/Free Full Text]
- Tanimoto K., Sugiyama F., Goto Y. et al. Angiotensinogen-deficient mice with hypotension. J Biol Chem 1994; 269; 31334-7.[Abstract/Free Full Text]
- Niimura F., Labosky PA, Kakuchi J. et al. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth regulation. J Clin Invest 1995; 96; 2947-54.[Web of Science][Medline]
[Order article via Infotrieve]
- Sharp MG, Fettes D., Brooker G. et al. Targeted inactivation of the Ren-2 gene in mice. Hypertension 1996;28:1126-31.[Abstract/Free Full Text]
- Krege JH, John SWM, Langenbach LL et al. Male-female differences in fertility and blood pressure in ACE deficient mice. Nature 1995; 375:146-8.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 1996; 74; 953-65.[Web of Science][Medline]
[Order article via Infotrieve]
- Ito M., Oliverio MI, Mannon PJ et al. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA 1995;92: 3521-5.[Abstract/Free Full Text]
- Sugaya T., Nishimatsu S., Tanimoto K. et al. Angiotensin II type 1a receptor deficient mice with hypotension and hyperreninemia. J Biol Chem 1995; 270:18719-22.[Abstract/Free Full Text]
- Chen X., Li W., Yoshida H. et al. Targeting deletion of angiotensin type 1B receptor gene in the mouse.AmJPhysiol 1997;272: F299-304.[Web of Science][Medline]
[Order article via Infotrieve]
- Tsuchida S., MatsusakaT, Chen X. et al. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.J Clin Invest 1998;101: 755-60.[Web of Science][Medline]
[Order article via Infotrieve]
- Ichiki T., Labosky PA, Shiota C. et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.Nature 1995;377:748-50.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Hein L., Barsh GS, Pratt RE, Dzau VJ, Kobilka BK Behavioural and cardiovascular efffects of disrupting the angiotensin II type-2 receptor gene in mice. Nature 1995;377: 744-7.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Krege JH, Hodgin JB, Hagaman JR, Smithies O. A noninvasive computerised tail-cuff system for measuring blood pressure in mice.Hypertension 1995;25;1111-5.[Abstract/Free Full Text]
- Borkowski JA, Ransom RW, Seabrook GR et al. Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem 1995;270: 13706-10.[Abstract/Free Full Text]
- Cushman DW, Cheung HS Concentration of the angiotensin-converting enzyme in tissues of rat. Biochimica et Biophysica Acta 1971;250:261-5.[Medline]
[Order article via Infotrieve]
- Ramaraj P., Kessler SP, Colmenares C., Sen GC: Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme. J Clin Invest 1998; 102: 371-8.[Web of Science][Medline]
[Order article via Infotrieve]
- Hagaman JR, Moyer JS, Bachman ES et al. Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci USA 1998; 95: 2552-7.[Abstract/Free Full Text]
- Esther CR, Marino EM, Howard TE et al. The critical role of the tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest 1997;99: 2375-85.[Web of Science][Medline]
[Order article via Infotrieve]
- CoffmanTM A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor. Semin in Nephrol 1997;17: 404-11.
- Okubo S., Niimura F., Nishimura F. et al. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. J Clin Invest 1997;99: 855-60.[Web of Science][Medline]
[Order article via Infotrieve]
Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2,
137-141 (2000)
DOI: 10.3317/jraas.2000.016

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