SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Renin-Angiotensin-Aldosterone System
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Williams, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williams, B.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*High Blood Pressure
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Editorial

The renin angiotensin system and cardiovascular disease: hope or hype?

Bryan Williams

Cardiovascular Research Institute, Faculty of Medicine & Biological Sciences, University of Leicester School of Medicine, Leicester, UK, bw17{at}le.ac.uk

Key Words: renin-angiotensin system • HOPE • blood pressure • diabetes

References

  • Lee MA, Bohm M., Paul M., Ganten D. Tissue renin angiotensin systems and their role in cardiovascular diseases. Circulation 1993; 87: 7-13.[Web of Science]
  • Berk BC, Vekshtein V., Gordon HM, Tsuda T. Angiotensin II stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension 1989;13:305-14.[Abstract/Free Full Text]
  • NaftilanAJ, Gilliland GK, Eldridge CS, KraftAS. Induction of the proto-oncogene c-jun by angiotensin II. Mol Cell Biol 1990; 10:5536-40.[Abstract/Free Full Text]
  • Kranzhofer R., Schmidt J., Pfeiffer CA, Hagl S., Libby P., Kubler W. Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1999; 19:1623-9.[Abstract/Free Full Text]
  • Himeno H., Crawford DC, Hosoi M., Chobanian AV, Brecher P. Angiotensin II alters aortic fibronectin independently of hypertension. Hypertension 1991; 23: 823-6.
  • Griendling K., Ollerenshaw JD, Minieri CA, Alexander RW Angiotensin II stimulates NADH and NADPH activity in cultured vascular smooth muscle cells. Circ Res 1994; 74: 1141-8.[Abstract/Free Full Text]
  • Rajagopaian S., Kurz S., Munzel T. et al. Angiotensin II mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. J Clin Invest 1996; 97:1916-23.[Web of Science][Medline] [Order article via Infotrieve]
  • Warnholtz A., Nickenig G., Schultz E. et al. Increased NADHoxidase-mediated superoxide production in the early stages of atherosclerosis; evidence for involvement of the reninangiotensin system. Circulation 1999; 99:2027-33.[Abstract/Free Full Text]
  • Strawn WB, Chappell MC, Dean RH, Kivlighn S., Ferrario CM Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolaemia. Circulation 2000; 101:1586-93.[Abstract/Free Full Text]
  • Williams B. Angiotensin II,VEGF and diabetic retinopathy. Lancet 1998; 351: 837-8.[Web of Science][Medline] [Order article via Infotrieve]
  • Birkenboom G. Unstable atherosclerotic plaque. Pathophysiology and therapeutic implications. Acta Cardiol 1998,53:235-41.[Web of Science][Medline] [Order article via Infotrieve]
  • The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987; 316:1429-35.[Abstract]
  • Pfeffer MA, Braunwald E., Moye LA et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med 1992; 27:669-77.
  • Williams B. The renin angiotensin system in the pathogenesis of diabetic complications. In: Mogensen CE (ed.) The kidney and hypertension in diabetes. Kluwer Academic publications 2000: 645-54.
  • Cooper ME Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet 1998;352:213-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Chaturvedi N., Sjolie A.-K, Stephenson JM et al. Effects of lisinopril on progression of retinopathy in normotensive people with type I diabetes. Lancet 1998; 351: 28-31.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hansson L., Lindholm LH, Niskanen L. et al. Effect of angiotensin-converting enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP). Lancet 1999; 353:611-615.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hansson L., Lindholm LH, Ekbom T. et al. Randomised trial of old and new hypertensive drugs in elderly patients: cardiovascular morbidity and mortality in the Swedish Trial of Old Patients with hypertension-2 study. Lancet 1999; 354:1751-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting enzyme inhibitor, ramipril, on cardiovascular events in high risk patients. N Eng J Med 2000; 342:145-53.[Abstract/Free Full Text]
  • The Heart Outcomes Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 2000; 355:253-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Williams B. Diabetes is a vascular disease. Acta Diabetol 1999; 36: 1-3.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Clarke R., Shipley M., Lewington S. et al. Underestimation of risk associations due to regression dilution in long term follow-up of prospective studies. Am J Epidemiol 1999; 150:341-53.[Abstract/Free Full Text]
  • Kannel WB Potency of vascular risk factors as the basis for antihypertensive therapy. Eur Heart J 1992;13(suppl G):34-42.[Free Full Text]
  • Williams B. The unique vulnerability of diabetic subjects to hypertensive injury. J Human Hypertension 1999;13:3-8.
  • Williams B. Treating hypertension in type 2 diabetes: An evidence base at last. Acta Diabetol 1999;36:4-10.
  • Hansson L., Zanchetti A., Carruthers SG et al for the HOT Study Group. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure and the National High Blood Pressure Education Program Coordinating Committee. The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med;157:2413-46.
  • Ramsay LE, Williams B., Johnston DG et al. British Hypertension Society guidelines for hypertension management 1999:A summary. BMJ 1999;319:630-5.[Free Full Text]
  • Tuomilehto J., Rastenyte D., Birkenhager WH et al. Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Syst Eur Investigators. N Eng J Med 1999;340:677-84.[Abstract/Free Full Text]
  • United Kingdom prospective diabetes study group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. UKPDS 38. BMJ 1998;317:703-13.[Abstract/Free Full Text]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2, 142-146 (2000)
DOI: 10.3317/jraas.2000.017


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
HeartHome page
M. J Brown
Renin: friend or foe?
Heart, September 1, 2007; 93(9): 1026 - 1033.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
B. Williams
Recent hypertension trials: Implications and controversies
J. Am. Coll. Cardiol., March 15, 2005; 45(6): 813 - 827.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Williams, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williams, B.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*High Blood Pressure
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Advertisement