This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kershenovich, A. Articles by Kadekaro, M. Search for Related Content PubMed PubMed Citation Articles by Kershenovich, A. Articles by Kadekaro, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Diabetic Kidney Problems Social Bookmarking                         What's this?

Angiotensin II does not mediate the pressor response to PGD2 (icv)

The University of Texas Medical Branch at Galveston, 301 University Blvd. Galveston, TX 77555-0517, USA

Mary Lee Terrell

The University of Texas Medical Branch at Galveston, 301 University Blvd. Galveston, TX 77555-0517, USA

Joan Y Summy-Long

Pennsylvania State University College of Medicine, 500 University Dr. Hershey, PA 17033, USA

Massako Kadekaro

The University of Texas Medical Branch at Galveston, 301 University Blvd. Galveston, TX 77555-0517, USA, mkutyna{at}utmb.edu

The objective of the present studies was to examine the interaction between brain-derived angiotensin II (Ang II) and prostaglandins in order to identify the mechanisms mediating the pressor response produced by these neuroregulators. Inhibiting synthesis of prostaglandins with indomethacin [indocin, 200 µg/ 5 µl artificial cerebrospinal fluid (aCSF)], administered intracerebroventricularly (icv) to conscious adult male Sprague-Dawley rats, reduced blood pressure to values below basal levels. When injected prior to Ang II (50 ng/5 µl aCSF; icv), indomethacin completely abolished the pressor response induced by the octapeptide. The increase in blood pressure produced by prostaglandin D₂ (PGD ₂, 20 µg/5 µl; icv), the most prominent prostaglandin in the rat brain, however, was not prevented by losartan (25 µg/5 µl; icv), an Ang II AT ₁-receptor antagonist. Collectively, these results indicate that prostaglandins produced tonically in the brain maintain resting arterial blood pressure and that the pressor action of Ang II is dependent on de novo synthesis of a prostaglandin.

Key Words: blood pressure • losartan • prostaglandin • Ang II AT1-receptor

References

• Liu H.,Terrell ML, Summy-Long JY, Kadekaro M. Brain ANG II and prostaglandins mediate the pressor response after central blockade of nitric oxide synthase. Brain Res 1998;785: 317-28.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Larsson, C., Weber P., Anggard E. Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbit. Eur J Pharm 1974;28:391-4.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• McGiff JC, Terragno NA, Malik KU et al. Release of a prostaglandin E-like substance from canine kidney by bradykinin. Circ Res 1972;31:36-43.[Abstract/Free Full Text]
• Mizuno K., Higashimori K., Inagami T. Direct evidence for the local generation of vascular angiotensin II and its prostaglandin-mediated release from isolated hind legs in the rat. J. Hypert Suppl 1988;6:S435-S437.
• Whorton AR, Misono K., Hollifield J., Frolich JC, Inagami T., Oates JA Prostaglandins and renin release: I. Stimulation of renin release from rabbit renal cortical slices by PGI2. Prostaglandins 1977;14:1095-104.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Diz DI, Baer PG, NasjlettiA. Angiotensin II-induced hypertension in the rat. Effects on the plasma concentration, renal excretion, and tissue release of prostaglandins. J Clin Invest 1983;72:466-77.[Web of Science][Medline] [Order article via Infotrieve]
• Hayaishi O. Prostaglandin D2: a neuromodulator. In: Samuelsson B, Paoletti RRP, (eds). Advances in Prostaglandin, Thromboxane and Leukotriene Research. Raven: New York, 1999:333-7.
• Inoue M., Crofton JT, Share L. Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. Exp Br Res 1990;83:131-6.[Web of Science][Medline] [Order article via Infotrieve]
• Terragno NA Prostaglandins, antidiuretic hormone and renin angiotensin system. Hypertension 1981;3( Suppl II):1165-70.
• Phillips MI, Sumners C. Angiotensin II in central nervous system physiology. Reg Pept 1998;78:1-11[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Zusman RM, Keiser HR Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin. J Clin Invest 1977; 60:215-33.
• Wolfe LS Possible roles of prostaglandins in the nervous system. In: Agranoff BW, Aprison MH, (eds). Advances in Neurochemistr. Plenum: New York, NY, 1975:1-49.
• Wolfe LS, Horrocks L. Eicosanoids: prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB, (eds). Basic Neurochemistry. Raven Press: New York, 1994:475-90.
• Gerozissis K., Saavedra JM, Dray F.Prostanoid profile in specific brain areas, pituitary and pineal gland of the male rat. Influence of experimental conditions. Brain Res 1983;279: 133-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bergmann BM, Landis CA, Zenko CE, Rechtschaffen, A. Sleep deprivation in the rat: XVII. Effect of aspirin on elevated body temperature. Sleep 1993;16:221-5.[Web of Science][Medline] [Order article via Infotrieve]
• Ojeda SR, Negro-Vilar A., McCann SM Role of prostaglandins in the control of pituitary hormone secretion. Prog Clin Biol Res 1981;74:229-47.[Medline] [Order article via Infotrieve]
• Hori T., Oka T., Hosoi M.,Aou S. Pain modulatory actions of cytokines and prostaglandin E2 in the brain. Ann NY Acad Sci 1998;840:269-81.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Doggett NS, Jawaharlal K. Some observations on the anorectic activity of prostaglandin F2 alpha. Br J Pharm 1977;60:409-15.[Web of Science][Medline] [Order article via Infotrieve]
• Bergstrom S., Farnebo LO, Fuxe K. Effect of prostaglandin E2 on central and peripheral catecholamine neurons. Eur J Pharm 1973;21:362-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hoffer BJ, Siggins GR, Bloom FE Possible cyclic AMP-mediated adrenergic synapses to rat cerebellar Purkinje cells: combined structural, physiological, and pharmacological analyses. Adv Biochem Psychopharmacol 1970;3:349-70.[Medline] [Order article via Infotrieve]
• Grbovic L., Radmanovic BZ, Prostaglandins E2 and F2 alpha and acetylcholinesterase activity in the slices of some structures in the cat's brain. Arch Int Physiol Bioch 1981;89:379-83.[CrossRef]
• Poulain P.,Carette B. Iontophoresis of prostaglandins on hypothalamic neurons. Brain Res 1974;79:311-4.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hoffman WE, Schmid PG Cardiovascular and antidiuretic effects of central prostaglandin E2. J Physiol 1979;288:159-69.[Abstract/Free Full Text]
• Yamamoto M., Share L., Shade RE Vasopressin release during ventriculo-cisternal perfusion with prostaglandin E2 in the dog. J Endocrinol 1976;71:325-31.[Abstract/Free Full Text]
• Brooks DP,Share L., Crofton JT et al. Central indomethacin enhances volume-dependent vasopressin release. Am J Physiol 1984;247: R1017-R1021.[Medline] [Order article via Infotrieve]
• Chai, SY, Mendelsohn FAO, Paxinos G. Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography. Neuroscience 1987;20:615-27.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Paul M., Bader M., Steckelings UM et al. The renin-angiotensin system in the brain. Localization and functional significance.Arzneimittel-Forschung 1993;43:207-13.[Medline] [Order article via Infotrieve]
• Unger T., Badoer E., Ganten D. et al. Brain angiotensin: pathways and pharmacology. Circulation 1988;77(Suppl I):140-54.
• Wright JW, Krebs LT, Stobb JW et al. The angiotensin IV system: functional implications. Front Neuroendocrinol 1995; 16:23-52.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hartle DK, Lind RW, Johnson AK et al. Localization of the anterior hypothalamic angiotensin II pressor system. Hypertension 1982;4:159-65.[Abstract/Free Full Text]
• Localization of angiotensin receptor binding sites in the rat brain. In: Bjorklund A, Hokfelt T,Kuban MJ, (eds). Handbook of Chem. Neuroanatomy. Elsevier: Amsterdam, 1992: 1-37.
• Mendelsohn FA, Quirion R., Saavedra JM et al. Autoradiographic localization of angiotensin II receptors in rat brain. Proc NatAcad Sci USA 1984;81:1575-79.[CrossRef]
• Plunkett LM, Shigematsu K., Kurihara M. et al. Localization of angiotensin II receptors along the anteroventral third ventricle area of the rat brain. Brain Res 1987;405:205-12.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Song K., Zhuo J.,Allen AM et al. Angiotensin II receptor subtypes in rat brain and peripheral tissues. Cardiology 1991;79(Suppl 1):45-54.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Mullins JJ, Peters J., Ganten D., Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 1990;344:541-4.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Senanayake PD, Moriguchi A., Kumagai H. et al. Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats. Peptides 1994;15:919-26.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Phillips MI, Hoffman WE Central actions of angiotensin and related hormones. In: Buckley JP, Ferrario CM (eds). Pergamon Pres: New York, 1997: 325-6.

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2, 195-200 (2000)
DOI: 10.3317/jraas.2000.025


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kershenovich, A. Articles by Kadekaro, M. Search for Related Content PubMed PubMed Citation Articles by Kershenovich, A. Articles by Kadekaro, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Diabetic Kidney Problems Social Bookmarking                         What's this?