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Pathological involvement of chymase-dependent angiotensin II formation in the development of cardiovascular disease

Department of Internal Medicine , Fukuoka University, School of Medicine, Fukuoka, Japan, uratah{at}fukuoka-u.ac.jp

Chymase is a potent and specific angiotensin II (Ang II)-forming enzyme in vitro. There is also strong evidence to suggest its importance in vivo. Recent clinical studies have suggested that high serum cholesterol levels are associated with increased vascular chymase activity and this may assist in the development of atherosclerosis. This clinical finding has been reproduced in hamster models. Studies with transgenic mice overexpressing the human chymase gene suggest a direct association between vascular chymase upregulation and atherogenesis. There is also increased chymase activity following various cardiac diseases such as myocardial ischaemia, volume overload cardiac failure, cardiomyopathy and viral myocarditis, suggesting that increased cardiac chymase activity appears to be involved in cardiac remodelling.

Key Words: chymase • heart failure • animal model • atherosclerosis • angiotensin II • Ang II receptor blocker • cardiac remodelling

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2 suppl, S35-S37 (2000)
DOI: 10.3317/jraas.2000.054


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Urata, H. Search for Related Content PubMed PubMed Citation Articles by Urata, H. Social Bookmarking                         What's this?