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Angiotensin receptor blocker selectivity at the AT1- and AT2-receptors: conceptual and clinical effects

Institute of Pharmacology, Universität zu Kiel, Kiel, Germany, th.unger@ pharmakologie

Steffen Sandmann

Institute of Pharmacology, Universität zu Kiel, Kiel, Germany

The advent of specific angiotensin II (Ang II) receptor blockers (ARBs) some ten years ago has provided substantial information on the specific actions of the AT₁- and AT₂-receptors. Most of the early research concentrated on the AT₁-receptor, and the actions and biological roles of the AT₂-receptor are much less well characterised. The AT₂-receptor is involved in the inhibition of cell proliferation, and in cell differentiation and development, regeneration and apoptosis. By raising local Ang II concentrations at the AT₂-receptor, selective blocking of the AT₁-receptor may therefore have beneficial effects. This concept may be important for antihypertensive therapy and in cardiovascular disease in general.

Key Words: angiotensin II AT2-receptor • Ang II receptor blocker • myocardial infarction • valsartan • intracellular pH regulation • Na+/H+ exchange

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 2 suppl, S6-S9 (2000)
DOI: 10.3317/jraas.2000.057


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Unger, T. Articles by Sandmann, S. Search for Related Content PubMed PubMed Citation Articles by Unger, T. Articles by Sandmann, S. Social Bookmarking                         What's this?