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Journal of Renin-Angiotensin-Aldosterone System
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Editorial

Gene therapy for hypertension and restenosis

Monica Gardon

Departments of Physiology and Pharmacodynamics, University of Florida, College of Medicine, Gainesville, FL 3260, USA

Mohan K Raizada

Departments of Physiology and Pharmacodynamics, University of Florida, College of Medicine, Gainesville, FL 3260, USA

Michael J Katovich

Departments of Physiology and Pharmacodynamics, University of Florida, College of Medicine, Gainesville, FL 3260, USA

Kathleen H Berecek

Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Craig H Gelband

Departments of Physiology and Pharmacodynamics, University of Florida, College of Medicine, Gainesville, FL 3260, USA, gelband{at}phys.med.ufl.edu

Key Words: hypertension • restenosis • gene therapy • angiotensin • RAAS • ion channels

References

  • Kang PM, Landau AJ, Eberhardt RT, Frishman WH Angiotensin II receptor antagonists: a new approach to blockade of the renin-angiotensin system. Am Heart J 1994;127(5):1388-401.1.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Elkind MS, Sacco RL Stroke risk factors and stroke prevention. Semin Neurol 1998;18(4):429-40.[Web of Science][Medline] [Order article via Infotrieve]
  • Stamler J., Stamler R., Neaton JD Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med 1993;153(5):598-615.[Abstract/Free Full Text]
  • Hall WD Risk reduction associated with lowering systolic blood pressure: review of clinical trial data. Am Heart J 1999;138(3 Pt 2):225-30.[CrossRef][Medline] [Order article via Infotrieve]
  • Dzau VJ Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Intern Med 1993;153(8):937-42.[Abstract/Free Full Text]
  • Raizada LD,Yang H., Richards EM, Gelband CH, Sumners C. Brain angiotensin receptor subtypes and their coupling to distinct signal transduction pathways. In: LeRoith D, editor. Advances in Molecular Cellular Endocriology. Stanford, CT: JAI Press; 1999:74-101.
  • Yamazaki T., Yazaki Y. Role of tissue angiotensin II in myocardial remodelling induced by mechanical stress. J Hum Hypertens 1999;13 Suppl 1:S43-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • van Zwieten PA Development and trends in the drug treatment of essential hypertension. J Hypertens Suppl 1992;10(7):S1-12.[Medline] [Order article via Infotrieve]
  • OByrne S., Caulfield M. Genetics of hypertension. Therapeutic implications. Drugs 1998;56(2):203-14.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jeunemaitre X., Soubrier F., Kotelevtsev YV et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992;71(1):169-80.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Davis GK, Roberts DH Molecular genetics of the renin-angiotensin system: implications for angiotensin II receptor blockade. Pharmacol Ther 1997;75(1):43-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Birkenhager WH, de Leeuw PW Non-peptide angiotensin type 1 receptor antagonists in the treatment of hypertension. J Hypertens 1999;17(7):873-81.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Villard E., Soubrier F. Molecular biology and genetics of the angiotensin-I-converting enzyme: potential implications in cardiovascular diseases. Cardiovasc Res 1996;32(6):999-1007.[Free Full Text]
  • Berglund L. A recurrent theme with a new spin:ACE polymorphism and cardiovascular disease [editorial; comment]. J Lab Clin Med 1998;131(6):485-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Bonnardeaux A., Davies E., Jeunemaitre X. et al.Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994;24(1):63-9.[Abstract/Free Full Text]
  • Poirier O., Georges JL, Ricard S. et al. New polymorphisms of the angiotensin II type 1 receptor gene and their associations with myocardial infarction and blood pressure: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Hypertens 1998;16(10):1443-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Kurtz TW, Simonet L., Kabra PM,Wolfe S., Chan L., Hjelle BL Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure. J Clin Invest 1990;85(4):1328-32.[Web of Science][Medline] [Order article via Infotrieve]
  • Jacob HJ, Lindpaintner K., Lincoln SE et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991;67(1):213-24.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hilbert P., Lindpaintner K., Beckmann JS et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991;353(6344):521-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Deng AY, Dene H., Rapp JP Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest 1994;94(1):431-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Merrill DC, Granwehr BP, Davis DR, Sigmund CD Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders. Proc Assoc Am Physicians 1997; 109(6):533-46.[Web of Science][Medline] [Order article via Infotrieve]
  • Stec DE, Sigmund CD Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Exp Nephrol 1998;6(6):568-75.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Kainulainen K., Perola M., Terwilliger J. et al. Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. Hypertension 1999;33(3):844-9.[Abstract/Free Full Text]
  • Kotelevtsev V., Clauser E., Corvol P., Soubrier F. Dinucleotide repeat polymorphism in the human angiotensinogen gene. Nucleic Acids Res 1991;19(24):6978.
  • St. Lezin E., Zhang L.,Yang Y. et al. Effect of chromosome 19 transfer on blood pressure in the spontaneously hypertensive rat. Hypertension 1999;33(1 Pt 2):256-60.[Abstract/Free Full Text]
  • Gyurko R., Wielbo D., Phillips MI Antisense inhibition of AT1-receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Regul Pept 1993;49(2):167-74.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wielbo D., Sernia C., Gyurko R., Phillips MI Antisense inhibition of hypertension in the spontaneously hypertensive rat. Hypertension 1995;25(3):314-9.[Abstract/Free Full Text]
  • Tomita N., Morishita R., Higaki J. et al.Transient decrease in high blood pressure by in vivo transfer of antisense oligodeoxynucleotides against rat angiotensinogen. Hypertension 1995;26(1):131-6.[Abstract/Free Full Text]
  • Phillips MI, Mohuczy-Dominiak D., Coffey M. et al. Prolonged reduction of high blood pressure with an in vivo, nonpathogenic, adeno-associated viral vector delivery of AT1-R mRNA antisense.Hypertension 1997;29(1 Pt 2):374-80.[Abstract/Free Full Text]
  • Zhang YC, Bui JD, Shen L., Phillips MI Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation 2000;101(6): 682-8.[Abstract/Free Full Text]
  • Zhang JJ, Chao L., Chao J. Adenovirus-mediated kallikrein gene delivery reduces aortic thickening and stroke-induced death rate in Dahl salt-sensitive rats. Stroke 1999;30(9): 1925-31.[Web of Science][Medline] [Order article via Infotrieve]
  • Chao J., Jin L., Lin KF, Chao L. Adrenomedullin gene delivery reduces blood pressure in spontaneously hypertensive rats. Hypertens Res 1997;20(4):269-77.[Medline] [Order article via Infotrieve]
  • Lin KF, Chao J., Chao L. Atrial natriuretic peptide gene delivery attenuates hypertension, cardiac hypertrophy, and renal injury in salt-sensitive rats. Hum Gene Ther 1998;9(10): 1429-38.[Web of Science][Medline] [Order article via Infotrieve]
  • Lin KF, Chao J., Chao L. Human atrial natriuretic peptide gene delivery reduces blood pressure in hypertensive rats. Hypertension 1995;26(6 Pt 1):847-53.[Abstract/Free Full Text]
  • Lin KF, Chao L., Chao J. Prolonged reduction of high blood pressure with human nitric oxide synthase gene delivery. Hypertension 1997;30(3 Pt 1):307-13.[Abstract/Free Full Text]
  • Iyer SN, Lu D., Katovich MJ, Raizada MK Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense. Proc Natl Acad Sci USA 1996;93(18):9960-5.[Abstract/Free Full Text]
  • Lu D., Raizada MK, Iyer S., Reaves P., Yang H., Katovich MJ Losartan versus gene therapy: chronic control of high blood pressure in spontaneously hypertensive rats. Hypertension 1997;30(3 Pt 1):363-70.[Abstract/Free Full Text]
  • Martens JR, Reaves PY, Lu D. et al. Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy. Proc Natl Acad Sci USA 1998;95(5):2664-9.[Abstract/Free Full Text]
  • Gelband CH, Sumners C., Lu D., Raizada MK Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling. Regul Pept 1998;73(3):141-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Katovich MJ, Gelband CH, Reaves P., Wang HW, Raizada MK Reversal of hypertension by angiotensin II type 1 receptor antisense gene therapy in the adult SHR. Am JPhysiol 1999;277(3 Pt 2):H1260-H1264.[Web of Science][Medline] [Order article via Infotrieve]
  • Yusuf S., Sleight P., Pogue J., Bosch J., Davies R., Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342(3):145-53.[Abstract/Free Full Text]
  • Wang H., Katovich MJ, Gelband CH, Reaves PY, Phillips MI, Raizada MK Sustained inhibition of angiotensin I-converting enzyme (ACE) expression and long-term antihypertensive action by virally mediated delivery of ACE antisense cDNA. Circ Res 1999;85(7):614-22.[Abstract/Free Full Text]
  • Gelband CH, Wang H., Gardon ML et al.Angiotensin I-converting enzyme antisense prevents altered renal vascular reactivity, but not high blood pressure, in spontaneously hypertensive rats. Hypertension 2000;35(1 Pt 2):209-13.[Abstract/Free Full Text]
  • Wang H., Reaves PY, Gardon ML et al. Angiotensin I-converting enzyme antisense gene therapy causes permanent antihypertensive effects in the SHR. Hypertension 2000;35(1 Pt 2):202-8.[Abstract/Free Full Text]
  • Heckmann U., Ottens E., Zidek W., Vetter H. A circulating hypertensive factor in primary hypertension: effect of antihypertensive therapy. Nephron 1987;47(Suppl 1):138-41.[Web of Science][Medline] [Order article via Infotrieve]
  • Zidek W., Ottens E., Heckmann U. Transmission of hypertension in rats by cross circulation. Hypertension 1989;14(1):61-5.[Abstract/Free Full Text]
  • McMurtry JP, Wright GL, Wexler BC Spontaneous hypertension in cross-suckled rats. Science 1981;211(4487):1173-5. 48. Bauters C., Isner JM The biology of restenosis. Prog Cardiovasc Dis 1997;40(2):107-16.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Association AH. 1999 Heart and Stroke Statistical Update. Dallas,TX: American HeartAssociation; 1999.
  • Simons M., Edelman ER, DeKeyser JL, Langer R., Rosenberg RD Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 1992; 359(6390):67-70.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Abe J., Zhou W., Taguchi J. et al. Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc2 and cdk2 oligonucleotides in rat carotid artery. Biochem Biophys Res Commun 1994;198(1):16-24.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Simons M., Edelman ER, Rosenberg RD Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model. J Clin Invest 1994;93(6):2351-6.[Web of Science][Medline] [Order article via Infotrieve]
  • Morishita R., Gibbons GH, Ellison KE et al. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest 1994;93(4):1458-64.[Web of Science][Medline] [Order article via Infotrieve]
  • Morishita R., Gibbons GH, Kaneda Y., Ogihara T., Dzau VJ Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery. Gene 1994;149(1):13-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Paquet JL, Baudouin-Legros M., Brunelle G., Meyer P. Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats. J Hypertens 1990;8(6): 565-72.[Web of Science][Medline] [Order article via Infotrieve]
  • Daemen MJ, Lombardi DM, Bosman FT, Schwartz SM. Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. Circ Res 1991;68(2):450-6.[Abstract/Free Full Text]
  • Osterrieder W., Muller RK, Powell JS, Clozel JP, Hefti F., Baumgartner HR Role of angiotensin II in injury-induced neointima formation in rats. Hypertension 1991;18(4 Suppl):1160-4.
  • Morishita R., Gibbons GH, Ellison KE et al. Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. J Clin Invest 1994;94(3):978-84.[Web of Science][Medline] [Order article via Infotrieve]
  • Morishita R., Gibbons GH, Tomita N. et al. Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function. Arterioscler Thromb Vasc Biol 2000;20(4):915-22.[Abstract/Free Full Text]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 3, 211-216 (2000)
DOI: 10.3317/jraas.2000.033


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