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Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction

Department of Pharmacology, University of Kiel, Germany, Department of Pharmacology, National University of Singapore, Singapore

Yi-Chun Zhu

Department of Pharmacology, University of Kiel, Germany, Department of Physiology, Shanghai Medical University, China

Jun Li

Department of Pharmacology, University of Kiel, Germany

Heiner Schäfer

Department of Internal Medicine, University Hospital of Kiel, Germany

Wolfgang Schmidt

Department of Internal Medicine, University Hospital of Kiel, Germany

Tai Yao

Department of Physiology, Shanghai Medical University, China

Thomas Unger

Department of Pharmacology, University of Kiel, Germany, th.unger@ pharmakologie

We investigated the haemodynamic parameters and the regulation of cardiac mRNA levels of the angiotensin receptor subtypes, AT₁ and AT₂, by the AT₁-receptor antagonist losartan in rat heart during the acute phase of myocardial infarction. AT₁- and AT₂-receptor mRNA levels markedly increased at 30 minutes and peaked at 24 hours post myocardial infarction (12.6-fold increase for AT₁- and 17.2-fold increase for AT₂ compared with controls). Losartan significantly reduced mean blood pressure in sham-operated rats and decreased mean blood pressure and left ventricular end-diastolic pressure in myocardial infarction rats. However, the AT₁- and AT₂-receptor mRNA levels of losartan-treated rats showed a pattern similar to that of water-treated rats. The time-dependent increase of AT ₁- and AT₂receptor mRNA levels is associated with the early remodelling process of non-infarcted myocardium post MI and is independent of AT₁-receptor blockade.

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 3, 257-262 (2000)
DOI: 10.3317/jraas.2000.039


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yi Zhun Zhu Articles by Unger, T. Search for Related Content PubMed PubMed Citation Articles by Yi Zhun Zhu, Articles by Unger, T. Social Bookmarking                         What's this?