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Genetic basis of cardiovascular disease — the renin-angiotensin-aldosterone system as a paradigm

MRC Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, UK

Sandosh Padmanabhan

MRC Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, UK

John MC Connell

MRC Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, UK, jmcc1m@ clinmed.gla.ac.uk

Key Words: genetics • blood pressure • cardiovascular diseases • genetic predisposition to disease • human • hypertension • aldosterone • cytochrome P-450 CYP11B2 • angiotensin I • angiotensin II • renin • renin-angiotensin system • myocardial infarction • hypertrophy • arteries • heart • endothelium

References

• Haas E., Goldblatt H. Kinetic constants of the human renin and human angiotensinogen reaction. Circ Res 1968; 20:45-55.[Medline] [Order article via Infotrieve]
• Pickens PT, Bumpus FM, Lloyd AM et al. A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate. Circulation 1994; 90:2207-12.[Abstract/Free Full Text]
• Kurtz TW, Simonet L., Kabra PM,Wolfe S., Chan L., Hjelle BL Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure. J Clin Invest 1990;85(4):1328-32.[Web of Science][Medline] [Order article via Infotrieve]
• Sun L., McArdle S., Chun M., Wolff DW, Pettinger WA Cosegregation of the renin gene with an increase in mean arterial blood pressure in the F2 rats of SHR-WKY cross. Clin Exp Hypertens 1993;15(5):797-805.[Web of Science][Medline] [Order article via Infotrieve]
• Naftilan AJ,Williams R., Burt D. et al. A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension. Hypertension 1989;14(6):614-8.[Abstract/Free Full Text]
• Soubrier F., Jeunemaitre X., Rigat B., Houot AM, Cambien F., Corvol P. Similar frequencies of renin gene restriction fragment length polymorphisms in hypertensive and normotensive subjects. Hypertension 1990;16(6):712-7.[Abstract/Free Full Text]
• Germain S., Bonnet F., Philippe J., Fuchs S., Corvol P., Pinet F. A novel distal enhancer confers chorionic expression on the human renin gene. J Biol Chem 1998;273(39):25292-300.[Abstract/Free Full Text]
• Kim HS, Krege JH, Kluckman KD et al. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 1995;92(7):2735-9.[Abstract/Free Full Text]
• Jeunemaitre X., Soubrier F., Kotelevtsev YV et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992 Oct 2;71(1):169-80.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Iwai N., Shimoike H., Ohmichi N., Kinoshita M. Angiotensinogen gene and blood pressure in the Japanese population. Hypertension 1995; 25:688-93.[Abstract/Free Full Text]
• Arngrimsson R., Purandare S., Connor M. et al. Angiotensinogen: a candidate gene involved in preeclampsia? Nat Genet 1993; 4:114-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Jeunemaitre X., Inoue I., Williams C. et al. Haplotypes of angiotensinogen in essential hypertension. American Journal of Human Genetics 1997; Jun; 60(6):1448-60.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Neel JV The genetics of diabetes mellitus. In Diabetes.Camerini.-Davalos R, Cole HS, editors. Academic. Press Inc., Orlando.Fl; 1970;3-10.
• Brand E., Chatelain N., Keavney B. et al. Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension 1998 Mar;31(3):725-9.[Abstract/Free Full Text]
• HingoraniAD, Sharma P., Jia H., Hopper R., Brown MJ Blood pressure and the M235T polymorphism of the angiotensinogen gene. Hypertension 1996 Nov;28(5):907-11.[Abstract/Free Full Text]
• Beige J., Zilch O., Hohenbleicher H. et al. Genetic variants of the renin-angiotensin system and ambulatory blood pressure in essential hypertension. Journal of Hypertension 1997;15(5): 503-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Caulfield M., Lavender P., Farrall M. et al. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 1994;330(23):1629-33.[Abstract/Free Full Text]
• Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86(4): 1343-6.[Web of Science][Medline] [Order article via Infotrieve]
• Danser AH, Schalekamp MA, Bax WA et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 1995;92(6):1387-8. 20. Tiret L., Rigat B., Visvikis S., Breda C., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I converting enzyme gene accounting for half the variance of serum enzyme levels. Am J Hum Genet 1992; 51:197-205.[Web of Science][Medline] [Order article via Infotrieve]
• Ueda S., Elliott HL, Morton JJ, Connell JM Enhanced pressor response to angiotensin I in normotensive men with the deletion genotype (DD) for angiotensin-converting enzyme. Hypertension 1995;25(6):1266-9.[Abstract/Free Full Text]
• Buikema H., Pinto YM, Rooks G., Grandjean JG, Schunkert H., van Gilst WH The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences in human arteries. Eur Heart J 1996;17(5):787-94.[Abstract/Free Full Text]
• Perticone F., Ceravolo R., Maio R. et al. Angiotensin-converting enzyme gene polymorphism is associated with endothelium-dependent vasodilation in never treated hypertensive patients. Hypertension 1998;31(4):900-5.[Abstract/Free Full Text]
• Cambien F., Evans A. Angiotensin I converting enzyme gene polymorphism and coronary heart disease. Eur Heart J 1995; 16 Suppl K:13-22.[Free Full Text]
• Ruiz J., Blanche H., Cohen N. et al. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1994; 91(9):3662-5.[Abstract/Free Full Text]
• Tiret L., Blanc H., Ruidavets JB et al. Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study. Projet d'Etude des Genes de l'Hypertension Arterielle Severe a moderee Essentielle. J Hypertens 1998;16 (1):37-44.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Lindpaintner K., Pfeffer MA, Kreutz R. et al. A prospective evaluation of an angiotensin-converting enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995;332(11):706-11.[Abstract/Free Full Text]
• Samani NJ,Thompson JR, O'Toole L., Channer K.,Woods KL A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation 1996;94(4):708-12.[Abstract/Free Full Text]
• Keavney B., McKenzie C., Parish S. et al. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 2000;355(9202):434-42.[Web of Science][Medline] [Order article via Infotrieve]
• Schunkert H., Hense HW, Holmer SR et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med 1994;330(23):1634-8.[Abstract/Free Full Text]
• Montgomery HE, Clarkson P., Dollery CM et al. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 1997;96(3):741-7.[Abstract/Free Full Text]
• Kupari M., Perola M., Koskinen P., Virolainen J., Karhunen PJ Left ventricular size, mass, and function in relation to angiotensin-converting enzyme gene polymorphism in humans. Am J Physiol 1994;267(3 Pt 2):H1107-H1111[Web of Science][Medline] [Order article via Infotrieve]
• Lindpaintner K., Lee M., Larson MG et al. Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. NEnglJMed 1996;334 (16):1023-8.[Abstract/Free Full Text]
• Raynolds MV, Perryman MBThe association between the angiotensin I converting enzyme gene polymorphism and cardiovascular disease. Coron Artery Dis 1995;6(4):302-9.[Web of Science][Medline] [Order article via Infotrieve]
• Busjahn A., Voss A., Knoblauch H. et al. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins. Am J Cardiol 1998;81(6):755-60.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hilbert P., Lindpaintner K., Beckmann JS et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991;353(6344):521-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Higashimori K., Zhao Y., Higaki J. et al. Association analysis of a polymorphism of the angiotensin-converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophys Res Commun 1993;191(2):399-404.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Jeunemaitre X., Lifton RP, Hunt SC, Williams RR, Lalouel JM Absence of linkage between the angiotensin-converting enzyme locus and human essential hypertension. Nat Genet 1992;1(1):72-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Duru K., Farrow S., Wang JM, Lockette W., Kurtz T. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension. Am J Hypertens 1994;7(8):759-62.[Web of Science][Medline] [Order article via Infotrieve]
• O'Donnell CJ, Lindpaintner K., Larson MG et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998;97(18):1766-72.[Abstract/Free Full Text]
• Julier C., Delepine M., Keavney B. et al. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Human Molecular Genetics 1997 Nov;6(12):2077-85.[Abstract/Free Full Text]
• Levy D., DeStefano AL, Larson MG et al. Evidence for a gene influencing blood pressure on chromosome 17: genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham heart study. Hypertension 2000;36(4):477-83.[Abstract/Free Full Text]
• Krege JH, Kim HS, Moyer JS et al. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension 1997;29(1 Pt 2):150-7.[Abstract/Free Full Text]
• Griendling KK, Ushio-Fukai M., Lassegue B., Alexander RW Angiotensin II signaling in vascular smooth muscle. New concepts. Hypertension 1997;29(1 Pt 2):366-73.[Abstract/Free Full Text]
• Regitz-Zagrosek V., Neuss M., Holzmeister J., Warnecke C., Fleck E. Molecular biology of angiotensin receptors and their role in human cardiovascular disease. J Mol Med 1996;74(5): 233-51.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• BonnardeauxA., Davies E., Jeunemaitre X. et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994 Jul;24(1):63-9.[Abstract/Free Full Text]
• Wang WY, Zee RY, Morris BJ Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clin Genet 1997;51(1):31-4.[Web of Science][Medline] [Order article via Infotrieve]
• Schmidt S., Beige J.,Walla-Friedel M., Michel MC, SharmaAM, Ritz E. A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension. J Hypertens 1997;15(12 Pt 1):1385-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Berge KE, Berg K. Polymorphisms at the angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) loci and normal blood pressure. Clin Genet 1998;53(3):214-9.[Web of Science][Medline] [Order article via Infotrieve]
• Tiret L., Bonnardeaux A., Poirier O. et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet 1994;344:910-3.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Berge KE, Bakken A., Bohn M., Erikssen J., Berg K. A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction. Clin Genet 1997;52(2):71-6.[Web of Science][Medline] [Order article via Infotrieve]
• Benetos A., Gautier S., Ricard S. et al. Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation 1996;94(4):698-703.[Abstract/Free Full Text]
• Benetos A., Cambien F., Gautier S. et al. Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals. Hypertension 1996; 28:1081-4.[Abstract/Free Full Text]
• Castellano M., Muiesan ML, Beschi M. et al. Angiotensin II type 1 receptor A/C1166 polymorphism: relationship with blood pressure and cardiovascular structure. Hypertension 1996; 28:1076-80.[Abstract/Free Full Text]
• Miller JA,Thai K., Scholey JW Angiotensin II type 1 receptor polymorphism predicts response to losartan and angiotensin II. Kidney International 1999; 56:2173-80.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Lifton RP, Dluhy RG, Powers M. et al. A chimaeric 11 betahydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992; Jan 16;355(6357):262-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Davies E., Holloway CD, Ingram MC et al. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Hypertension 1999;33(2):703-7.[Abstract/Free Full Text]
• White PC, Slutsker L. Haplotype analysis of CYP11B2. Endocr Res 1995;21(1-2):437-42.[Web of Science][Medline] [Order article via Infotrieve]
• Kupari M., Hautanen A., Lankinen L. et al. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Circulation 1998;97(6):569-75.[Abstract/Free Full Text]
• Ylitalo A.,Airaksinen KE, Hautanen A. et al. Baroreflex sensitivity and variants of the renin angiotensin system genes. J Am Coll Cardiol 2000;35(1):194-200.[Abstract/Free Full Text]
• Schunkert H., Hengstenberg C., Holmer SR et al. Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation 1999; 99(17):2255-60.[Abstract/Free Full Text]
• Pojoga L., Gautier S., Blanc H. et al. Genetic determination of plasma aldosterone levels in essential hypertension. Am J Hypertens 1998;11(7):856-60.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Lim PO, Macdonald TM, Holloway C. et al. Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone to renin ratio- Annual Scientific Meeting of the British Hypertension Society, Cambridge, UK, 11-13 September 2000. J Hum Hypertens 14(12), 837-856.

Journal of Renin-Angiotensin-Aldosterone System, Vol. 1, No. 4, 316-324 (2000)
DOI: 10.3317/jraas.2000.060


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This Article Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Padmanabhan, N. Articles by Connell, J. M. Search for Related Content PubMed PubMed Citation Articles by Padmanabhan, N. Articles by Connell, J. M. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?