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Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension

Division of Endocrinology and Metabolism, Beijing Tongren Hospital affiliated to Capital Medical University, Beijing, China

Jin-Kui Yang

Division of Endocrinology and Metabolism, Beijing Tongren Hospital affiliated to Capital Medical University, Beijing, China, jinkui.yang@ gmail.com

Introduction. We performed a meta-analysis to assess the association of ACE2 G8790A polymorphism with essential hypertension.

Materials and methods. The references were retrieved through MEDLINE, Wanfang and VIP Information.The analyses were performed by the software STATA 9.0.

Results. No significant publication bias was observed.The combined data showed no association of the frequencies of the A allele with essential hypertension odds ratio (OR)=1.09 95% confidence interval (CI)=0.98—1.20;p=0.11 in female patients. No associations were shown between the frequencies of the A allele with the genetic susceptibility to essential hypertension in male patients (OR=1.11 95% CI=0.95—1.29; p=0.19).

Conclusion. The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population.

Key Words: ACE2 G8790A • genetic susceptibility meta-analysis

References

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 1, 31-34 (2009)
DOI: 10.1177/1470320309103047


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Zhou, J.-B. Articles by Yang, J.-K. Search for Related Content PubMed PubMed Citation Articles by Zhou, J.-B. Articles by Yang, J.-K. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Medline Plus Health Information High Blood Pressure Social Bookmarking                         What's this?