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Association of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene with type 2 diabetes in two ethnic groups of Jerba Island in Tunisia
Thouraya Baroudi
Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, El Manar II University, 2092 Tunis, Tunisia, Thourbar{at}yahoo.fr
Rym Bouhaha
Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, El Manar II University, 2092 Tunis, Tunisia
Chrystine Moran-Moguel
Division of Molecular Medicine, Centre of Biomedical Research for West, The Mexican Institute of the Social Security, Guadalajara, Jalisco, Mexico
Jose Sanchez-Corona
Division of Molecular Medicine, Centre of Biomedical Research for West, The Mexican Institute of the Social Security, Guadalajara, Jalisco, Mexico
Hedi Ben Maiz
Hospital Charles Nicolle, Internal Medicine A, 1060 Tunis, Tunisia
Hafaoua Kammoun Abid
Hospital Charles Nicolle, Internal Medicine A, 1060 Tunis, Tunisia
Amel Benammar-Elgaaied
Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, El Manar II University, 2092 Tunis, Tunisia
Introduction.The aim of the current study was to evaluate the role of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the prediction of type 2 diabetes in two ethnic populations from Jerba Island,Tunisia.
Methods. In this study, we analysed the genotypic and the allelic distributions of the ACE I/D polymorphism and conducted a case/control association study between healthy normoglycaemic controls and diabetic patients in the two studied groups.ACE gene polymorphism was analysed by polymerase chain reaction in 272 individuals consisting of 172 diabetic subjects and 100 controls.
Results.The genotype frequencies for DD, ID and II were 75.50%, 19.60% and 4.89% inArabs and 76.66%, 16.66% and 6.67% in Berbers, respectively, in the case group, and 42.85%, 35.71% and 21.43% inArabs and 57.50%, 22.50% and 20.00% in Berbers, respectively, in the control group.The DD frequency was significantly higher in the case group than in the control group (p<0.001), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study populations.
Conclusions.The current investigation provides new evidence regarding the role of the ACE I/D polymorphism in the pathogenesis of type 2 diabetes in Jerbian populations. Furthermore, it underlines the importance of ethnicity, which should be considered in all studies aiming to test the genetic effects on the susceptibility to type 2 diabetes.
Key Words: angiotensin-converting enzyme • diabetes • ethnicity • insertion/deletion polymorphism • Tunisian populations
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Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 1,
35-40 (2009)
DOI: 10.1177/1470320309102314
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