|
Sign In to gain access to subscriptions and/or personal tools.
|
Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population
Jian-Kang Yang
Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China
Yuan-Ying Gong
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Liang Xie
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China, Graduate University of the Chinese Academy of Sciences, Beijing, China
Shi-Gang Lian
People's Hospital of Dujiang Weirs City, Dujiang Weirs City, China
Juan Yang
People's Hospital of Dujiang Weirs City, Dujiang Weirs City, China
Liang-You Xu
Dujiangyan Longevity Research Centre, Dujiangyan, China
Shou-Jun Gao
Dujiangyan Longevity Research Centre, Dujiangyan, China
Ya-Ping Zhang
Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China, zhangyp1@263. net.cn, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Introduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population.
Materials and methods. We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years.
Results. No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884).
Conclusions. No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population.
Key Words: angiotensin-converting enzyme • Han Chinese population • longevity • polymorphism
References
- Terry DF, Evans JC, Pencina MJ et al. Characteristics of Framingham offspring participants with long-lived parents. Arch Intern Med 2007;167:438-44.[Abstract/Free Full Text]
- Herskind AM, McGue M., Holm NV, Sorensen TI, Harvald B., Vaupel JW The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet 1996;97:319-23.[Web of Science][Medline]
[Order article via Infotrieve]
- vB Hjelmborg J., Iachine I., Skytthe A. et al. Genetic influence on human lifespan and longevity. Hum Genet 2006;119:312-21.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Christensen K., Johnson TE, Vaupel JW The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet 2006;7:436-48.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Castellon R., Hamdi HK Demystifying the ACE polymorphism: from genetics to biology. Curr Pharm Des 2007; 13:1191-8.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Panza F., D'Introno A., Capurso C. et al. Lipoproteins, vascular-related genetic factors, and human longevity. Rejuvenation Res 2007;10:441-58.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Schächter F., Faure-Delanef L., Guénot F. et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994;6:29-32.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Blanché H., Cabanne L., Sahbatou M., Thomas G. A study of French centenarians: are ACE and APOE associated with longevity? C R Acad Sci III 2001;324:129-35.[Medline]
[Order article via Infotrieve]
- Nacmias B., Bagnoli S., Tedde A. et al. Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity. Arch Gerontol Geriatr 2007;45:201-06.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Choi YH, Kim JH, Kim DK et al. Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. J Gerontol A Biol Sci Med Sci 2003;58:227-31.[Web of Science][Medline]
[Order article via Infotrieve]
- Seripa D., Franceschi M., Matera MG et al. Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. J Gerontol A Biol Sci Med Sci 2006;61:918-23.[Web of Science][Medline]
[Order article via Infotrieve]
- Rahmutula D., Nakayama T., Izumi Y. et al. Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study. J Gerontol A Biol Sci Med Sci 2002;57:M57-60.[Web of Science][Medline]
[Order article via Infotrieve]
- Wufuer M., Fang MW, Cheng ZH, Qiu CC Polymorphism of angiotensin coverting enzyme gene and natural longevity in the Xinjiang Uygur people: an association study. Natl Med J China 2004;84:1603-06. (in Chinese)
- Forero DA, Pinzón J., Arboleda GH et al. Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein E genes and human longevity in Colombia. Arch Med Res 2006;37:890-4.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Lindpaintner K., Pfeffer MA, Kreutz R. et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995;332:706-11.[Abstract/Free Full Text]
- Bladbjerg EM, Andersen-Ranberg K., de Maat MP et al. Longevity is independent of common variations in genes associated with cardiovascular risk. Thromb Haemost 1999;82:1100-05.[Web of Science][Medline]
[Order article via Infotrieve]
- Panza F., Solfrizzi V., D'Introno A. et al. Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe. Exp Gerontol 2003;38:1015-20.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Galinsky D., Tysoe C., Brayne CE et al. Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. Atherosclerosis 1997;129:177-83.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Hessner MJ, Dinauer DM, Kwiatkowski R., Neri B., Raife TJ Age-dependent prevalence of vascular disease-associated polymorphisms among 2689 volunteer blood donors. Clin Chem 2001;47:1879-84.[Abstract/Free Full Text]
- Yan CL, Zhan JB, Feng WB Gene polymorphisms of angiotensin II type 1 receptor and angiotensin-converting enzyme in two ethnic groups living in Zhejiang Province, China. J Renin Angiotensin Aldosterone Syst 2005;6:132-7.[Abstract/Free Full Text]
- Daimon M., Oizumi T., Saitoh T. et al. The D allele of the angiotension-converting enzyme insertion/deletion (I/D) polymorphism is a risk factor for type 2 diabetes in a population-based Japanese sample. Endocr J 2003;50:393-8.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Da Cruz IB, Oliveira G., Taufer M. et al. Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age. J Gerontol A Biol Sci Med Sci 2003;58:851-6.[Web of Science]
Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 2,
115-118 (2009)
DOI: 10.1177/1470320309104873
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
|
|
