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Journal of Renin-Angiotensin-Aldosterone System
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Perindopril decreases P wave dispersion in patients with stage 1 hypertension

Beste Ozben

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey, bestes{at}doctor.com

Mutlu Sumerkan

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Azra Meryem Tanrikulu

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Nurdan Papila-Topal

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Ali Serdar Fak

Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

Ahmet Toprak

Department of Internal Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey

Introduction. Angiotensin-converting enzyme inhibitors prevent atrial fibrillation episodes by effective control of blood pressure and improving electrical and structural remodelling in the atria. Increased P wave dispersion (PWD) is a non-invasive electrocardiographic marker for paroxysmal atrial fibrillation. The aim of the study was to evaluate the effect of perindopril treatment on PWD in hypertensive patients. Methods. Forty-eight hypertensive patients (mean age 57.4±11.8 years, 18 men) were included. Blood pressure values were determined and 12-lead electrocardiograms were recorded at the beginning and at the first week, first month, third month and sixth month of the perindopril treatment.The difference between maximum and minimum P wave durations was calculated as PWD.

Results. PWDs were significantly shortened at the first, third and sixth months (41.7±8.8 ms, 39.1±6.9 ms and 38.3±7.1 ms, respectively) compared with baseline and first-week measurements (54.3±9.2 ms and 49.0±9.1 ms, respectively, p<0.001). Baseline PWD was correlated with body mass index (r=0.32, p=0.026), while PWD at the sixth month of treatment was significantly correlated with left atrial volume index (r=0.30, p=0.042). Multiple linear regression analysis revealed that PWD at the sixth month was related to baseline PWD (p=0.001).

Conclusion. Perindopril treatment significantly reduced PWD in hypertensive patients.

Key Words: angiotensin-converting enzyme inhibitor • atrial fibrillation • electrocardiography • hypertension • perindopril • P wave dispersion

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 2, 85-90 (2009)
DOI: 10.1177/1470320309105199
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This Article
Right arrow Abstract Freely available
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Citing Articles
Right arrow Citing Articles via Scopus
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Right arrow Articles by Ozben, B.
Right arrow Articles by Toprak, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ozben, B.
Right arrow Articles by Toprak, A.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*High Blood Pressure
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