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Journal of Renin-Angiotensin-Aldosterone System
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Efficacy in angiotensin receptor blockade: a comparative review of data with olmesartan

Josep Redon

Hypertension Clinic, Hospital Clínico Universitario, University of Valencia, Valencia, Spain, josep.redon{at}uv.es, CIBER 03/06 Physiopathology of Obesity and Nutrition, Institute of Health Carlos , Minister of Health, Spain

Maria Jose Fabia

Hypertension Clinic, Hospital Clínico Universitario, University of Valencia, Valencia, Spain, CIBER 03/06 Physiopathology of Obesity and Nutrition, Institute of Health Carlos , Minister of Health, Spain

A range of angiotensin II receptor blockers (ARB) is available, and analyses suggest there are differences between agents in terms of antihypertensive efficacy and 24-hour blood pressure control.This review assesses the data comparing olmesartan with other ARBs in terms of blood pressure reductions, goal achievement, 24-hour control and speed of onset. Olmesartan seems to have a more favourable efficacy profile relative to standard doses of the ARBs used in comparative studies; results consistent with the high degree of blockade of the angiotensin II type 1 receptor for olmesartan.Taken together, there might be differences between ARBs regarding their blood pressure lowering efficacy, and these results may provide further support of the benefits of olmesartan therapy since choice of an effective agent is crucial in antihypertensive therapy.

Key Words: angiotensin receptor blocker • blood pressure • hypertension • olmesartan • renin-angiotensin-aldosterone system

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This version was published on September 1, 2009

Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 3, 147-156 (2009)
DOI: 10.1177/1470320309342735
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