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Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Baddela Muni Venkata Srikanth Babu

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Kolla Venkata Karunakar

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Jeedigunta Yasovanthi

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India

Potham Sampath Kumar

Osmania General Hospital, Afzul Gunj, Hyderabad-500012, India

Annam Sharath

Osmania General Hospital, Afzul Gunj, Hyderabad-500012, India

Akka Jyothy

Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad-500016, India, jyothycell{at}rediffmail.com

Introduction. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients.

Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction.

Results. Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was ² = 2.08, odds ratio 2.30, 95% confidence interval 0.72 — 7.23, and p value was 0.14.

Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.

Key Words: A1166C polymorphism • angiotensin II type 1 receptor • myocardial infarction • polymerase chain reaction • South Indian population

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 10, No. 3, 174-178 (2009)
DOI: 10.1177/1470320309342758


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Scopus Google Scholar Articles by Bhoomi Reddy Pullareddy Articles by Jyothy, A. PubMed PubMed Citation Articles by Bhoomi Reddy Pullareddy, Articles by Jyothy, A. Social Bookmarking                         What's this?