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Review: Structural requirements for signalling and regulation of AT1-receptors

Department of Physiology, Semmelweis University Medical School, Budapest, Hungary, Hunyady{at}puskin.sote.hu

Zsuzsanna Gáborik

Department of Physiology, Semmelweis University Medical School, Budapest, Hungary

Georges Vauquelin

Department of Molecular and Biochemical Pharmacology, Institute of Molecular Biology and Biotechnology, Free University of Brussels (VUB), Sint-Genesius Rode, Belgium

Kevin J Catt

Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA

Key Words: angiotensin II • G protein • Ca2+ signal • tyrosine kinase • receptor phosphorylation • receptor internalisation • candesartan

References

• Hunyady L., Balla T., Catt KJ The ligand binding site of the angiotensin AT1 receptor. Trends Pharmacol Sci 1996; 17:135-40.[CrossRef][Medline] [Order article via Infotrieve]
• Timmermans PB Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics. Hypertens Res 1999; 22:147-53.[Medline] [Order article via Infotrieve]
• Jagadeesh G. Angiotensin II receptors: antagonists, molecular biology, and signal transduction. Indian J Exp Biol 1998; 36:1171-94.[Medline] [Order article via Infotrieve]
• De Gasparo M., Catt KJ, Inagami T., Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000; 52:415-72.[Abstract/Free Full Text]
• Goodfriend TL, Elliott ME, Catt KJ Drug therapy- Angiotensin receptors and their antagonists. N Engl J Med 1996; 334:1649-54.[Free Full Text]
• Dostal DE The cardiac renin-angiotensin system: novel signaling mechanisms related to cardiac growth and function. Regul Pept 2000; 91:1-11.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Eguchi S., Inagami T. Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept 2000; 91:13-20.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Haendeler J., Berk BCAngiotensin II mediated signal transduction. Important role of tyrosine kinases. Regul Pept 2000; 95:1-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Inagami T., Eguchi S., Numaguchi K. et al. Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases. J Am Soc Nephrol 1999; 10:S57-S61.[Web of Science][Medline] [Order article via Infotrieve]
• Griendling KK, Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 2000; 91:21-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Thomas WG Regulation of angiotensin II type 1 (AT1) receptor function. Regul Pept 1999; 79:9-23.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hunyady L., Catt KJ, Clark AJ, Gáborik Z. Mechanisms and functions of AT(1) angiotensin receptor internalization. Regul Pept 2000; 91:29-44.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Thomas WG,ThekkumkaraTJ, Baker KM Molecular mechanisms of angiotensin II (AT1A) receptor endocytosis. Clin Exp Pharmacol Physiol 1996; Suppl.3:S74-S80.
• Gáborik Z., Szaszák M., Szidonya L. et al. β-arrestin- and dynamin-dependent endocytosis of the AT1 angiotensin receptor. Mol Pharmacol 2001; 59: 239-47.[Abstract/Free Full Text]
• Ferguson SSG, Barak LS, Zhang J., Caron MG G-protein-coupled receptor regulation: Role of G-protein-coupled receptor kinases and arrestins. Can J Physiol Pharmacol 1996; 74:1095-110.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Krupnick JG, Benovic JLThe role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 1998; 38:289-319.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Lefkowitz RJ G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 1998; 273:18677-80.[Free Full Text]
• Luttrell LM, Daaka Y., Lefkowitz RJ Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 1999; 11:177-83.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bumpus FM Mechanisms and sites of action of newer angiotensin agonists and antagonists in terms of activity and receptor. Fed Proc 1977; 36:2128-32.[Web of Science][Medline] [Order article via Infotrieve]
• Karnik SS, Husain A., Graham RM Molecular determinants of peptide and non-peptide binding to the AT1 receptor. Clin Exp Pharmacol Physiol 1997; Suppl. 3:S58-S66.
• Noda K., Feng YH, Liu XP, Saad Y., Husain A., Karnik SS The active state of the AT1 angiotensin receptor is generated by angiotensin II induction. Biochemistry 1996; 35:16435-42.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Noda K., Saad Y., Karnik SS Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation. J Biol Chem 1995; 270:28511-14.[Abstract/Free Full Text]
• Yamano Y., Ohyama K., Chaki S., Guo D.-F. Inagami T. Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. Biochem Biophys Res Commun 1992; 187:1426-31.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Fierens FL, Vanderheyden PM, Gáborik Z. et al. Lys199 mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmuntable non-peptide antagonists.JRAAS 2000; 1:283-87.[Medline] [Order article via Infotrieve]
• Thomas WG, Qian H., Chang CS, Karnik S. Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state. J Biol Chem 2000; 275:2893-900.[Abstract/Free Full Text]
• Miura S., Feng YH, Husain A., Karnik SS Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor. J Biol Chem 1999; 274:7103-10.[Abstract/Free Full Text]
• Balmforth AJ, Lee AJ, Warburton P., Donnelly D., Ball SGThe conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII. J Biol Chem 1997; 272:4245-51.[Abstract/Free Full Text]
• GroblewskiT, Maigret B., Larguier R., Lombard C., Bonnafous JC, Marie J. Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation. J Biol Chem 1997; 272:1822-26.[Abstract/Free Full Text]
• Perlman S., Costa-Neto CM, Miyakawa AA et al. Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: Susceptibility to receptor mutations. Mol Pharmacol 1997; 51:301-11.[Abstract/Free Full Text]
• Hunyady L., Ji H., Jagadeesh G. et al. Dependence of AT1 angiotensin receptor function on adjacent asparagine residues in the seventh transmembrane helix. Mol Pharmacol 1998; 54:427-34.[Abstract/Free Full Text]
• Feng YH, Miura S., Husain A., Karnik SS Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111). Biochemistry 1998; 37:15791-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Joseph MP, Maigret B., Bonnafous JC, Marie J., Scheraga HA A computer modeling postulated mechanism for angiotensin II receptor activation. J Protein Chem 1995; 14:381-98.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Böhm SK, Grady EF, Bunnett NW Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J1997; 322:1-18.
• Barak LS,Tiberi M., Freedman NJ, Kwatra MM, Lefkowitz RJ, Caron MG A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated β2-adrenergic receptor sequestration. J Biol Chem 1994; 269:2790-5.[Abstract/Free Full Text]
• Ferguson SSG, Ménard L., Barak LS, Koch WJ, Colapietro AM, Caron MG Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration - Rescue of a sequestration-defective mutant receptor by βARK1. J Biol Chem 1995; 270:24782-9.[Abstract/Free Full Text]
• Slice LW, Wong HC, Sternini C., Grady EF, Bunnett NW, Walsh JH The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence. J Biol Chem 1994; 269:21755-62.[Abstract/Free Full Text]
• Hunyady L., Bor M., Baukal AJ, Balla T., Catt KJ A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J Biol Chem 1995; 270:16602-09.[Abstract/Free Full Text]
• Laporte SA, Servant G., Richard DE, Escher E., Guillemette G., Leduc R. The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization. Mol Pharmacol 1996; 49:89-95.[Abstract]
• Monnot C., Bihoreau C., Conchon S., Curnow KM, Corvol P., Clauser E. Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling - Reconstitution of the binding site by co-expression of two deficient mutants. J Biol Chem 1996; 271:1507-13.[Abstract/Free Full Text]
• Conchon S., Monnot C., Teutsch B., Corvol P., Clauser E. Internalization of the rat AT1A and AT1B receptors: Pharmacological and functional requirements. FEBS Lett 1994; 349:365-70.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Crozat A., Penhoat A., Saez JM Processing of angiotensin II (A-II) and (Sar1,Ala8)A-II by cultured bovine adrenocortical cells. Endocrinology 1986; 118:2312-18.[Abstract/Free Full Text]
• Hunyady L., Merelli F., Baukal AJ, Balla T., Catt KJ Agonist-induced endocytosis and signal generation in adrenal glomerulosa cells. A potential mechanism for receptor-operated calcium entry. J Biol Chem 1991; 266:2783-8.[Abstract/Free Full Text]
• Tarasova NI, Stauber RH, Choi JK et al. Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein - Endocytosis and recycling of cholecystokinin receptor type A. J Biol Chem 1997; 272:14817-24.[Abstract/Free Full Text]
• Hunyady L., BaukalAJ, Balla T., Catt KJ Independence of type 1 angiotensin II receptor endocytosis from G protein coupling and signal transduction. J Biol Chem 1994; 269:24798-804.[Abstract/Free Full Text]
• Conchon S., Barrault M-B., Miserey S., Corvol P., Clauser E. The C-terminal third intracellular loop of the rat AT1A angiotensin receptor plays a key role in G protein coupling specificity and transduction of the mitogenic signal. J Biol Chem 1997; 272:25566-72.[Abstract/Free Full Text]
• Ohyama K.,YamanoY, Chaki S., KondoT., InagamiT. Domains for G-protein coupling in angiotensin II receptor type I: Studies by site-directed mutagenesis. Biochem Biophys Res Commun 1992; 189:677-83.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Wang C., Jayadev S., Escobedo JA Identification of a domain in the angiotensin II type 1 receptor determining Gq coupling by the use of receptor chimeras. J Biol Chem 1995; 270:16677-82.[Abstract/Free Full Text]
• Hunyady L., Zhang M., Jagadeesh G., Bor M., Balla T., Catt KJ Dependence of agonist activation on a conserved apolar residue in the third intracellular loop of the AT1 angiotensin receptor. Proc Natl Acad Sci USA 1996; 93:10040-5.[Abstract/Free Full Text]
• Zhang M., Zhao X., Chen HC, Catt KJ, Hunyady L. Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop. J Biol Chem 2000; 275:15782-8.[Abstract/Free Full Text]
• SanoT., Ohyama K.,Yamano Y. et al.A domain for G protein coupling in carboxyl-terminal tail of rat angiotensin II receptor type 1A. J Biol Chem 1997; 272:23631-6.[Abstract/Free Full Text]
• Gáborik Z., Mihalik B., Jayadev S., Jagadeesh G., Catt KJ, Hunyady L. Requirement of membrane-proximal amino acids in the carboxyl-terminal tail for expression of the rat AT1A angiotensin receptor. FEBS Lett 1998; 428:147-51.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Miura S., Zhang J., Karnik SS Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD. FEBS Lett 2000; 470:331-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Chaki S., Guo D.-F., Yamano Y. et al. Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor. Kidney Int 1994; 46:1492-5.[Web of Science][Medline] [Order article via Infotrieve]
• Hunyady L., Bor M., Balla T., Catt KJ Critical role of a conserved intramembrane tyrosine residue in angiotensin II receptor activation. J Biol Chem 1995; 270:9702-05.[Abstract/Free Full Text]
• Laporte SA, Roy SF, Escher E., Guillemette G., Leduc R. Essential role of leucine222 in mediating signal transduction of the human angiotensin II type 1 receptor. Receptors Channels 1998; 5:103-12.[Web of Science][Medline] [Order article via Infotrieve]
• Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM, Baker KM Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein. J Biol Chem 1994; 269:31443-9.[Abstract/Free Full Text]
• Marrero MB, Schieffer B., Paxton WG et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 1995; 375:247-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Ali MS, Sayeski PP, Dirksen LB, Hayzer DJ, Marrero MB, Bernstein KE Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J Biol Chem 1997; 272:23382-8.[Abstract/Free Full Text]
• Venema RC, Ju H., Venema VJ et al. Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptor. J Biol Chem 1998; 273:7703-08.[Abstract/Free Full Text]
• Ali MS, Schieffer B., Delafontaine P., Bernstein KE, Ling BN, Marrero MB Angiotensin II stimulates tyrosine phosphorylation and activation of insulin receptor substrate 1 and protein-tyrosine phosphatase 1D in vascular smooth muscle cells. J Biol Chem 1997; 272:12373-9.[Abstract/Free Full Text]
• Hunyady L., Bor M., Balla T., Catt KJ Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor. J Biol Chem 1994; 269:31378-82.[Abstract/Free Full Text]
• Schmitz U., Ishida T., Ishida M. et al. Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK. Circ Res 1998; 82:1272-8.[Abstract/Free Full Text]
• Haendeler J., Ishida M., Hunyady L., Berk BCThe third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways. Circ Res 2000; 86:729-36.[Abstract/Free Full Text]
• Luttrell LM, Ferguson SS, Daaka Y. et al. Beta-arrestindependent formation of beta2 adrenergic receptor-Src protein kinase complexes [see comments]. Science 1999; 283:655-61. 65. Ma YC, Huang J., Ali S., Lowry W., Huang XY Src tyrosine kinase is a novel direct effector of G proteins. Cell 2000; 102:635-46.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Dikic I.,Tokiwa G., Lev S., Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996; 383:547-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Prenzel N., Zwick E., Daub H. et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402:884-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bishop AL, HallA. Rho GTPases and their effector proteins. Biochem J 2000; 348:241-55.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Seasholtz TM, Majumdar M., Brown JH Rho as a mediator of G protein-coupled receptor signaling. Mol Pharmacol 1999; 55:949-56.[Free Full Text]
• Macrez N., Morel JL, Kalkbrenner F., Viard P., Schultz G., Mironneau J. A βgamma dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. JBiol Chem 1997; 272:23180-5.[Abstract/Free Full Text]
• YamakawaT.,Tanaka S., Numaguchi K. et al. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension 2000; 35:313-8.[Abstract/Free Full Text]
• Mitchell R., McCulloch D., Lutz E. et al. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature 1998; 392:411-4.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bihoreau C., Monnot C., Davies E. et al. Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling. Proc Natl Acad Sci USA 1993; 90:5133-7.[Abstract/Free Full Text]
• Hunyady L., Tian Y., Sandberg K., Balla T., Catt KJ Divergent conformational requirements for angiotensin II receptor internalization and signaling. Kidney Int 1994; 46:1496-8.[Web of Science][Medline] [Order article via Infotrieve]
• Thomas WG, Thekkumkara TJ, Motel TJ, Baker KM Stable expression of a truncated AT1A receptor in CHO-K1 cells. The carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization. J Biol Chem 1995; 270:207-13.[Abstract/Free Full Text]
• Balmforth AJ, Lee AJ, Bajaj BPS, Dickinson CJ, Warburton P., Ball SG Functional domains of the C-terminus of the rat angiotensin AT1A receptor. Eur J Pharmacol Mol Pharmacol 1995; 291:135-41.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Conchon S., Peltier N., Corvol P., Clauser E. A noninternalized nondesensitized truncated AT1A receptor transduces an amplified ANG II signal. Am J Physiol Endocrinol Metab 1998; 274:E336-E345.[Abstract/Free Full Text]
• Thomas WG, Baker KM, Motel TJ, Thekkumkara TJ Angiotensin II receptor endocytosis involves two distinct regions of the cytoplasmic tail. A role for residues on the hydrophobic face of a putative amphipathic helix. J Biol Chem 1995; 270:22153-9.[Abstract/Free Full Text]
• Smith RD, Hunyady L., Olivares-Reyes JA, Mihalik B., Jayadev S., Catt KJ Agonist-induced phosphorylation of the angiotensin AT1a receptor is localized to a serine/threonine-rich region of its cytoplasmic tail. Mol Pharmacol 1998; 54:935-41.[Abstract/Free Full Text]
• Thomas WG, Motel TJ, Kule CE, Karoor V., Baker KM Phosphorylation of the angiotensin II (AT1A) receptor carboxyl terminus:A role in receptor endocytosis. Mol Endocrinol 1998; 12:1513-24.[Abstract/Free Full Text]
• Palczewski K., Kumasaka T., Hori T. et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000; 289:739-45.[Abstract/Free Full Text]
• Vauquelin G., Fierens FL, De Backer JP, Vanderheyden PMThe effects of candesartan on human AT1 receptor-expressing Chinese hamster ovary cells. J Am Soc Nephrol 1999; 10:S15-S17.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 1 suppl, S16-S23 (2001)
DOI: 10.1177/14703203010020010301


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