This Article Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Frohlich, E. D Search for Related Content PubMed PubMed Citation Articles by Frohlich, E. D Social Bookmarking                         What's this?

Review: Promise of prevention and reversal of target organ involvement in hypertension

Alton Ochsner Medical Foundation, New Orleans, LA 70121 USA, efrohlich{at}ochsner.org

Key Words: hypertensive heart disease • coronary heart disease • left ventricular hypertrophy • ventricular ischaemia • ventricular fibrosis • coronary haemodynamics • end-stage renal disease • renal micropuncture • antihypertensive therapy

References

• Joint National Committee on Prevention, detection, evaluation, and treatment of high blood pressure. The Sixth Report of the Joint National Committee (JNC-VI) on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 1997; 157:2413-46.[Abstract/Free Full Text]
• Collins C., Peto R., MacMahon S. et al. Blood pressure, stroke and coronary heart disease. Part II. Short-term reductions in blood pressure overview of randomized drug trials in their epidemiological context. Lancet 1990; 335:827-38.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Thijs L., Fagard R., Lijuen F., Staessen J.,Van Hoof R.,Amery A. A meta-analysis of outcome trials in elderly hypertensives. J Hypertens 1992; 10:1103-09.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• WHO-ISH Hypertension Guidelines Committee. 1999 World Health Organization - In ternational Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens 1999;17:151-85.[Web of Science][Medline] [Order article via Infotrieve]
• McKee PA, Castelli WP, McNamara OM, Kannel WB The natural history of congestive heart failure. The Framingham Heart Study. N Engl J Med 1971; 285:1441-6.[Web of Science][Medline] [Order article via Infotrieve]
• Vasan RS, Levy D. The role of hypertension in the pathogenesis of heart failure: A clinical mechanistic overview. Arch Intern Med 1996; 156:1789-96.[Abstract/Free Full Text]
• Vasan RS, Benjamin EJ, Levy D. Prevalence, clinical features and prognosis of diastolic heart failure:An epidemiologic perspective.JAm Coll Cardiol 1995; 26:156.
• Frohlich ED Current clinical pathophysiologic considerations in essential hypertension. Med Clin North Am, 1997;81:1113-29.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Frohlich ED Risk mechanisms in hypertensive heart disease. Hypertension 1999; 34:782-9.[Abstract/Free Full Text]
• Frohlich ED In Hypertension: Evaluation and Treatment. (Chapter 7). Williams &Wilkins: Baltimore 1998; 119-40.
• Nixenberg A.,Antony I. Epicardial coronary arteries are not adequately sized in hypertensive patients. J Am Coll Cardiol 1996; 27:1115-23.
• Weber KT, SunY., Guarda E. Structural remodeling in hypertensive heart disease and the role of hormones. Hypertension 1994; 23:869-77.[Abstract/Free Full Text]
• Weber KT Extracellular matrix remodeling in heart failure: A role for de novo angiotensin II generation. Circulation 1997; 96:4065-82.[Free Full Text]
• Marcus ML, Duty DB, Hiratska LF,Wright CB, Eustham CL Decreased coronary reserve:A mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. N Engl J Med 1982; 307:1362-7.[Abstract]
• Opherk D., Nall G., Zebe H. et al. Reduction of coronary reserve:A mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. Circulation 1984; 69:1-7.[Abstract/Free Full Text]
• Brash JE, Jr, Cannon RO, Schenke WH et al. Angina due to coronary microvascular disease in hypertension without left ventricular hypertrophy. N Engl J Med 1988; 319:1302-07.[Abstract]
• Houghton JL, Frank MJ, Carr AA, von Dohlen TW, Prisant LM Relations among impaired coronary flow reserve: left ventricular hypertrophy and thallium perfusion defects in hypertensive patients without destructive coronary artery disease. J Am Coll Cardiol 1990;15:43-51.[Abstract]
• Scheler S., Wolfgang M., Strauer BE Mechanisms of angina pectoris with essential hypertension and normal epicardial arteries by arteriogram. Am JCardiol 1994; 73:478-82.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Treasure CB, Klein JL, Vita JA et al. Hypertenion and left ventricular hypertrophy are associated with impaired endothelium-mediated relazation in human coronary resistance vessels. Circulation 1993;87:86-93.[Abstract/Free Full Text]
• Lüscher TF The endothelium in hypertension: bystander, target or mediator? J Hypertension 1994; 12: 105-16.[Web of Science][Medline] [Order article via Infotrieve]
• Küng CF, Lüscher TF Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension 1995; 25:194-200.[Abstract/Free Full Text]
• Gauthier-Rein KM, Rusch NJ Distinct endothelial impairment in coronary microvessels from hypertensive Dahl rats. Hypertension 1998; 31:328-34.[Abstract/Free Full Text]
• Zeiher AM, Drexler H., Saurbier B., Just H.: Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 1993; 92:652-62.[Web of Science][Medline] [Order article via Infotrieve]
• Drexler H., Zeiher AM, Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 1991; 338: 1546-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bøttchen M., Bøtker HE, Sonne H., Nielsen TT, Czernin J. Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with Syndrome X. Circulation 1999; 99:1795-801.[Abstract/Free Full Text]
• Frohlich ED,Apstein C., Chobanian AV et al. The heart in hypertension. N Engl J Med 1992; 327:998-1008.[Web of Science][Medline] [Order article via Infotrieve]
• Kannel WB, Dawber TR, Kagan A., Revorskie N., Sacks J. Factors of risk in the development of coronary heart disease - six year follow up experience. The Framingham Study. Ann Intern Med 1961; 55:33-56.[Abstract/Free Full Text]
• Kannel WB, Gordon T., Offut D. Left ventricular hypertrophy by electrocardiogram: prevalence, incidence and mortality in the Framingham Study. Ann Intern Med 1969; 71:99-105.
• Frohlich ED Is reversal of left ventricular hypertrophy in hypertension beneficial? Hypertension 1991; 18(I):133-38.[Web of Science]
• Frohlich ED The First Irvine H. Page Lecture:The mosaic of hypertension: Past, present, and future. J Hypertens 1988; 6:S2-11.[Web of Science]
• Kozakova M., Polumbo C., Parati L., Pittella G., Galetta F., L'Abbate A. Mechanisms of coronary flow reserve impairment in human hypertension: An integrated approach by transthoracic and trans-esophageal echocardiography. Hypertension 1997; 29:551-9.[Abstract/Free Full Text]
• Sakoshima J., Izumo S.The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 1997; 59:551-71.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev 1999; 79:216-62.
• Nishiyama K., Nishiyama A., Frohlich ED Regional blood flow in normotensive and spontaneously hypertensive rats.Am J Phyiol 1976; 230:691-8.
• Tsuchiya M., Ferrone RA, Walsh GM, Frohlich ED Regional blood flows measured in conscious rats by the combined Fick and microsphere methods. Am J Physiol 1978; 235:H357-360.[Web of Science][Medline] [Order article via Infotrieve]
• Ishise S., Pegram BL, Yamamoto J., Kitamura Y., Frohlich ED Reference sample microsphere method: Cardiac output and blood flows in conscious rats. Am J Physiol 1980; 239:H443-449.[Web of Science][Medline] [Order article via Infotrieve]
• Soria F., Frohlich ED,Aristizabal D. et al. Preserved cardiac performance with reduced left ventricular mass in conscious exercising spontaneously hypertensive rats. J Hypertens 1994; 12:585-9.[Web of Science][Medline] [Order article via Infotrieve]
• Nunez E., Hosoya K., Susic D., Frohlich ED Enalapril and losartan reduced cardiac mass and improved coronary hemodynamics in SHR. Hypertension 1997; 29:519-24.[Abstract/Free Full Text]
• Susic D., Nunez, Hosoya H, Frohlich ED Coronary hemodynamics in aging spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. J Hypertens 1998; 16:231-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Rossi MA Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens 1998;16:1031-41.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Folkow B. The Fourth Vollrad Lecture: Cardiovascular structural adaptation: Its role in the initiation and maintenance of primary hypertension. Clin Sci Mol Med 1975; 48:205s-14s.
• Susic D., Frohlich ED Pharmacologic agents on cardiovascular mass and coronary hemodynamics in aging spontaneously hypertensive rats. J Hypertens 1999; 17:1-7.[Web of Science][Medline] [Order article via Infotrieve]
• Varagic J., Susic D., Frohlich ED AT2 receptors contribute to hypotension and antifibrosis but not coronary hemodynamic improvement or reduced LV mass, by AT1 receptor inhibition. Hypertension (in press).
• Schwartzkopff B., Brehm M., Mundhenke M., Strauer BE Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. Hypertension 2000; 36:220-5.[Abstract/Free Full Text]
• Brilla CG, Funck RC, Rupp H. Lisinopril-mediated regression of myocardial fibrosis in patieints with hypertensive heart disease. Circulation 2000; 102(12): 1388-99.[Abstract/Free Full Text]
• Arita M., Horinaka S., Frohlich ED Biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats. J Hypertens 1993;11:951-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Arita M., Horinaka S., Komatsu K., Frohlich ED Reversal of left ventricular hypertrophy with different classes of drugs causes differing ventricular biochemical changes. J Hypertens 1993; 11:S354-S355.[Web of Science]
• Aristizabal D., Messerli FH, Frohlich ED Disparate structural effects of left and right ventricles by angiotensin converting enzyme inhibitors and calcium antagonists. Am J Cardiol 1994; 73:483-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Susic D., Francischetti A., Frohlich ED Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive rats and normal rats. Hypertension 1999; 33:451-5.[Abstract/Free Full Text]
• Susic D.,Varagic J.,Frohlich ED L-arginine with angiotensin-converting enzyme inhibition improves cardiac function and coronary dynamics in two year old Wistar Kyoto rats. Hypertension (in press)
• US Renal Data Systems. 1995 Annual Data Report. National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases, III: incidence and causes of treated ESRD. Am J Kidney Dis 1995; 26:S39-S50.
• Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM Hyperfiltration in remnant nephros: a potentially adverse response to renal ablation. Am J Physiol 1981:241:F85-F93.[Web of Science][Medline] [Order article via Infotrieve]
• Brenner BM, Meyer TW, Hostetter TH Dietary protein intake and the progressive nature of kidney disease: the tale of hemodynamically mediated glomerular disease in the pathogenesis of progressive glomerular schlosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 1982; 3007:652-9.
• Anderson PW, Doy S., Hsueh WA Angiotensin II causes mesangial cell hypertrophy. Hypertension 1993; 21:166-72.[Abstract/Free Full Text]
• Mulrow PJ The intrarenal renin-angiotensin system. Curr Opin Nephrol Hypertens 1993; 2:41-4.[Medline] [Order article via Infotrieve]
• Lewis EJ, Hunsicker LG, Bain RP, Rohde RD The effect of angiotensin-converting-enzyme inhibition on diabetic nephropath. The Collaborative Study Group. N Engl J Med 1993; 320:1456-62.
• Ukpds Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes. UKPDS 39. BMJ 1998; 317:713-20.[Abstract/Free Full Text]
• Hansson L., Lindholm LH, Niskanen L. et al. Effects of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 1999; 353(9153):611-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Sowers JR, Epstein M., Frohlich ED Diabetes, hypertension and cardiovascular disease:An update. Hypertension (in press) 60. UKPDS Group. UK Prospective Diabetes Study 38: Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. BMJ 1998; 317:703-13.[Abstract/Free Full Text]
• Frohlich ED Arthur C. Corcoran Memorial Lecture: Influence of nitric oxide and angiotensin II on renal involvement in hypertension. Hypertension 1997; 29(part 2):188-93.[Abstract/Free Full Text]
• Ono H., Ono Y., Frohlich ED: Nitric oxide synthase inhibition in spontaneously hypertensive rats. Hypertension 1995;26: 249-55.[Abstract/Free Full Text]
• Komatsu K., Frohlich ED, Ono H., Ono Y., Numabe A., Willis GW Glomerular dynamics and morphology of aged SHR. Hypertension 1995; 25:207-13.[Abstract/Free Full Text]
• Uchino K., Frhlich ED, Nishikimi T., Isshiki T., Kardon MB Spontaneously hypertensive rats demonstrate increased renal vascular alpha 1 adrenergic receptor responsiveness. Am J Physiol 1991; 260:R889-R893.[Web of Science][Medline] [Order article via Infotrieve]
• Uchino K., Nishikimi T., Frohlich ED Alpha-1 adrenergic receptor blockade reduces afferent and efferent glomerular arteriolar resistance in SHR. Am J Physiol 1991; 261:R576-R580.[Web of Science][Medline] [Order article via Infotrieve]
• Ono H., Ono Y., Frohlich ED ACE inhibition prevents and reverses L-NAME-exacerbated nephrosclerosis in spontaneusly hypertensive rats. Hypertension 1996;27:176-83.[Abstract/Free Full Text]
• Ono Y., Ono H., Frohlich ED Hydrochlorothiazide exacerbates nitric oxide blockades nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats. J Hypertens 1996; 14:823-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• FrancischettiA, Ono H., Frhlich ED Renoprotective effects of felodipine and/or enalapril in spontaneously hypertensive rats with and without L-NAME. Hypertension 1998; 31:795-801.[Abstract/Free Full Text]
• Nakamura Y., Ono H., Zhou X., Frohlich ED Angiotensin type 1 receptor antagonism and ACE inhibition produce similar renoprotection in L-NAME/SHR rats. Hypertension (in press).
• Ono H., Ono Y., Frohlich ED L-Arginine reverses severe nephrosclerosis in aged spontaneously hypertensive rats. J Hypertens 1999; 17:121-8.[Web of Science][Medline] [Order article via Infotrieve]
• Nakamura Y., Ono H., Frohlich ED Differential effect of T-and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats. Hypertension 1999; 34:273-8.[Abstract/Free Full Text]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 1 suppl, S4-S9 (2001)
DOI: 10.1177/14703203010020010101


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Frohlich, E. D Search for Related Content PubMed PubMed Citation Articles by Frohlich, E. D Social Bookmarking                         What's this?