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Effects of low-dose candesartan on the rate of re-endothelialisation following vascular wound healing

Departments of Pharmacology and Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA

Amanda Self

Departments of Pharmacology and Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA

Philip J Kadowitz

Departments of Pharmacology and Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA

Vivian A Fonseca

Departments of Pharmacology and Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA

Dennis B McNamara

Departments of Pharmacology and Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA, dmcnama@ tulane.edu

The wound healing response of the vascular wall to injury involves re-endothelialisation of the denuded luminal surface and thickening of the intimal area (intimal hyperplasia), as expressed by the intimal-to-medial area ratio (I/M). Candesartan, at doses of 1 mg/kg/day or higher, has been reported to attenuate the intimal hyperplastic response. We tested the hypothesis that candesartan, at doses lower than those associated with attenuation of intimal hyperplasia, may affect re-endothelialisation. New Zealand White rabbits were subjected to balloon catheter injury to the thoracic aorta. Candesartan, at doses of 50, 100, and 500 µg/kg/day, was delivered via an Alzet pump placed in the abdomen one week prior to aortic injury. There was no attenuation of the hyperplastic response of the aortic wall. However, at 50 µg/kg/day the rate of reendothelialisation was significantly increased. These data suggest that candesartan may exhibit pleiotropic effects on vascular wound healing, in addition to the well-known effect of attenuating the development of intimal hyperplasia.

Key Words: vascular wound healing • intimal hyperplasia • re-endothelialisation • angiotensin • angiotensin receptor antagonist

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 1 suppl, S81-S83 (2001)
DOI: 10.1177/14703203010020011401


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Koshy, P. Articles by McNamara, D. B Search for Related Content PubMed Articles by Koshy, P. Articles by McNamara, D. B Social Bookmarking                         What's this?