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Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function

Section of Endocrinology and Menopause, Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany

Caroline Lippert

Section of Endocrinology and Menopause, Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany

Diethelm Wallwiener

Section of Endocrinology and Menopause, Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany

Alfred O Mueck

Section of Endocrinology and Menopause, Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany, endo.meno@ med.uni-tuebingen.de

The angiotensin II (Ang II) AT₁-receptor antagonists, valsartan and candesartan, were compared with regard to their effect on Ang II-mediated changes in parameters of coronary endothelial function. Ang II (10 µM) induced increased concentrations of the vasoconstrictor endothelin, the procoagulatory substance plasminogen-activator-inhibitor-1 (PAI-1) and the precursor of the matrix-metalloproteinase 1 (MMP-1) in endothelial cell cultures from human coronary arteries. These increases were completely prevented by the addition of 10 µM valsartan or candesartan and partially by the addition of lower concentrations of these drugs, i.e. 1 µM and 0.1 µM. No significant difference between the effect of the two AT₁-receptor antagonists was observed.

These results suggest that AT₁-receptor antagonists not only can reduce blood pressure by blocking the action of Ang II, but might also contribute to the prevention of atherogenesis and plaque instability.

Key Words: valsartan • candesartan • angiotensin II • coronary endothelial function

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 2, 141-143 (2001)
DOI: 10.3317/jraas.2001.016


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