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Journal of Renin-Angiotensin-Aldosterone System
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Angiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-II and Val-HeFT?

John JV McMurray

CRI in Heart Failure, Wolfson Building, University of Glasgow, Glasgow, G12 8QQ, UK, j.mcmurray{at}bio.gla.ac.uk

Key Words: angiotensin II • antagonists • receptor • heart failure • clinical trials

References

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  • Pitt B., Poole-Wilson P., Segal R. et al. Effects of losartan versus captopril on mortality in patients with symptomatic heart failure: rationale, design and baseline characteristics of patients in the Losartan Heart Failure Survival Study - ELITE II. J Card Fail 1999;5:146-54.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pitt B., Poole-Wilson PA, Segal R. et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial -- the Losartan Heart Failure Survival Study ELITE II. Lancet 2000;355:1582-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Tsuyuki RT, Yusuf S., Rouleau JL et al. Combination neurohormonal blockade with ACE inhibitors, angiotensin II antagonists and beta-blockers in patients with congestive heart failure: Design of the Randomized Evaluation of Strategies for Left Ventricular Dysfunction (RESOLVD) Pilot Study. Can J Card 1997;13:1166-74.
  • McKelvie RS,Yusuf S., Pericak D. et al. Comparison of candesartan, enalapril and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. Circulation 1999;100:1056-64.[Abstract/Free Full Text]
  • Cohn JN, Tognoni G., Glazer RD, Spormann D., Hester A. Rationale and design of the Valsartan Heart Failure Trial: a large multinational trial to assess the effects of valsartan, an angiotensin-receptor blocker, on morbidity and mortality in chronic congestive heart failure. J Card Fail 1999;5:155-60.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wolny A., Clozel JP, Rein J. et al. Functional and biochemical analysis of angiotensin II forming pathways in the human heart. Circulation Research 1997;80:219-27.[Abstract/Free Full Text]
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  • Petrie MC, Padmanabhan N., McDonald JE, Hillier C., Connell JMC, McMurray JJV. Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease. J Am Coll Cardiol 2001;37:1056-61.[Abstract/Free Full Text]
  • Siragy HM, Carey RM Angiotensin type 2 receptors: potential importance in the regulation of blood pressure. Curr Opin Nephrol Hypertens 2001;1:99-103.
  • Berry C., Norrie J.,McMurray J. Are Angiotensin II receptor blockers more efficacious than placebo in heart failure? implications of ELITE-2. Am J Cardiol 2001;87:606-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Horton R. From star signs to trial guidelines. Lancet 2000; 55:1033-4.
  • Pfeffer MA, McMurray J., Leizorovicz A. et al. Valsartan in acute myocardial infarction trial - VALIANT: rationale and design. Am Heart J 2000;140:727-50.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Swedberg K., Pfeffer M., Granger C. et al. Candesartan in heart failure-assessment of reduction in mortality and morbidity (CHARM): rationale and design. J Card Fail 1999;3:5276-82.

Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 2, 89-92 (2001)
DOI: 10.3317/jraas.2001.017


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J. J.V. McMurray, M. A. Pfeffer, K. Swedberg, and V. J. Dzau
Which Inhibitor of the Renin-Angiotensin System Should Be Used in Chronic Heart Failure and Acute Myocardial Infarction?
Circulation, November 16, 2004; 110(20): 3281 - 3288.
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