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Review: The renin-angiotensin system in the brain: an update
Juraj Culman
Institute of Pharmacology, Christian-Albrechts-University of Kiel, 24105 Kiel, juraj.culman@pharmakologie. uni.kiel.de
Johannes Baulmann
Medizinische Poliklinik, Rheinische-Friedrich-Wilhelms-University of Bonn, 53111 Bonn, Germany
Annegret Blume
Institute of Pharmacology, Christian-Albrechts-University of Kiel, 24105 Kiel
Thomas Unger
Institute of Pharmacology, Christian-Albrechts-University of Kiel, 24105 Kiel
Key Words: angiotensin AT1-receptor AT2-receptor renin-angiotensin system cell growth differentiation tissue regeneration apoptosis stroke central nervous system
References
- de Gasparo M., Catt KJ, Inagami T., Wright JW, Unger Th. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52(3):415-72.
- Höhle S., Blume A., Lebrun C., Culman J., Unger T. Angiotensin receptors in the brain. Pharmacol Toxicol 1995;77(5):306-15.[Web of Science][Medline]
[Order article via Infotrieve]
- McKinley MJ, McAllen RM, Mendelsohn FAO, Allen AM, Chai SY, Oldfield BJ Circumventricular organs: Neuroendocrine interfaces between the brain and hemal millieu. Front Neuroendocrinol 1990;11:91-127.[Web of Science]
- Muratami H., Teruya H., Sesoko S., Takishita S., Fukiyama K. Brain angiotensin and circulatory control. Clin Exp Pharmacol Physiol 1996;23:458-64.[Web of Science][Medline]
[Order article via Infotrieve]
- Fitzsimons JT Angiotensin, thirst, and sodium appetite. Physiol Rev 1998;78:583-686.[Abstract/Free Full Text]
- Davisson RL, Oliviero MI, Coffman TM, Sigmund CD Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 2000;106:103-6.[Web of Science][Medline]
[Order article via Infotrieve]
- Veltmar A., Culman J., Qadri F., Rascher W., Unger T. Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin II-induced vasopressin release. J Pharmacol Exp Ther 1992;263(3):1253-60.[Abstract/Free Full Text]
- Culman J., Hohle S., Qadri F., Edling O., Blume A., Lebrun C., Unger Th. Angiotensin as neuromodulator/neurotransmitter in central control of body fluid and electrolyte homeostasis. Clin Exp Hypertens 1995;17(1-2):281-93.[Web of Science][Medline]
[Order article via Infotrieve]
- Lenkei Z., Corvol P., Llorens-Cortes C. Comparative expression of vasopressin and angiotensin type-1 receptor mRNA in rat hypothalamic nuclei: a double in situ hybridization study. Mol Brain Res 1995;34:135-42.[Medline]
[Order article via Infotrieve]
- Saavedra JM Brain and pituitary angiotensin. Endocr Rev 1992;13(2):329-80.[Abstract/Free Full Text]
- Phillips MI Antisense inhibition and adeno-associated viral vector delivery for reducing hypertension. Hypertension 1997;29:177-87.[Abstract/Free Full Text]
- Nakamura S., Moriguchi A., Morishita R. et al. Activation of brain angiotensin system by in vivo human angiotensin-converting enzyme gene transfer in rats. Hypertension 1999;34:302-8.[Abstract/Free Full Text]
- Paton JRF, Kasparov S. Sensory channel specific modulation in the nucleus of the solitary tract. J Autonom Nerv Syst 2000;80:117-29.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Unger T.h. The angiotensin type 2 receptor: variations on an enigmatic theme. J Hypertens 1999;17:1775-86.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Lucius R., Gallinat S., Busche S., Rosenstiel P., Unger T.h. Beyond blood pressure: new roles for angiotensin II. Cell Mol Life Sci 1999;56:1008-19.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Seltzer AM, Zorad S., Saavedra JM Stimulation of angiotensin II AT1 receptors in rat median eminence increases phosphoinositide hydrolysis. Brain Res 1995;705(1-2):24-30.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Yang H., Lu D.,Yu K., Raizada MK Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway. J Neurosci 1996;16(13):4047-58.[Abstract/Free Full Text]
- Lu D.,Yang H., Raizada MK Angiotensin II regulation of neuromodulation: Downstream signaling mechanism from activation of mitogen-activated protein kinase. J Cell Biol 1996; 135:1609-17.[Abstract/Free Full Text]
- Yang H., Lu D.,Vinson GP, Raizada MK Involvement of MAP kinase in Angiotensin II-induced phosphorylation and intracelllar targeting of neuronal AT1 receptors. J Neurosci 1997; 17:1660-9.[Abstract/Free Full Text]
- Huang XC, Richards EM, Sumners C. Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors.JBiol Chem 1996;271(26):15635-41.[Abstract/Free Full Text]
- Yu K., Lu D., Rowland NE, Raizada MK.Angiotensin II regulation of tyrosine hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats. Endocrinology 1996;137(8):3566-76.[Abstract]
- Yang H., Raizada MK MAP kinase-independent signaling in angiotensin II regulation of neuromodulation in SHR neurons. Hypertension 1998;32:473-81.[Abstract/Free Full Text]
- Zhu M., Neubig RR, Wade SM, Posner P., Gelband CH, Sumners C. Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide. Am J Physiol 1997;273:C1040-C1048.[Web of Science][Medline]
[Order article via Infotrieve]
- Zhu M., Gelband CH, Posner P., Sumners C. Angiotensin II type 1 receptor-mediated inhibition of voltage-dependent K+ current in cultured neurons: role of calcium/calmodulin-dependent protein kinase. FASEB J 1998;12:A54.
- Yang CR, Phillips MI, Renaud LP Angiotensin II receptor activation depolarizes rat supraoptic neurons in vitro. Am J Physiol 1992;321:R1333-R1338.
- Huang XC, Deng T., Sumners C. Angiotensin II stimulates activation of Fos-regulating kinase and c-Jun NH2-terminal kinase in neuronal cultures from rat brain. Endocrinology 1998;139(1):245-51.[Abstract/Free Full Text]
- Yang CR, Raizada MK Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat. J Neurosci 1999;19:2413-23.[Abstract/Free Full Text]
- Herbert J., Forsling ML, Howes SR, Stacey PM, Shiers HM Regional expression of c-fos antigen in the basal forebrain following intraventricular infusion of angiotensin and its modulation by drinking either water or saline. Neuroscience 1992;51:867-82.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Blume A., Herdegen T., Unger T.h. Angiotensin peptides and inducible transcription factors. J Mol Med 1999;77:339-57.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Rowland NE, Li BH, Fregly MJ, Smith GC Fos induced in brain of spontaneously hypertensive rats by angiotensin II and colocalization with AT1 receptors. Brain Res 1995;675:127-34.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Blume A., Lebrun CJ, Herdegen T. et al. Increased brain transcription factor expression in genetic hypertension. Hypertension 1997; 29:592-8.[Abstract/Free Full Text]
- Nouet I., Nahmias I. Signal transduction from the angiotensin II AT2 receptor. Trends Endocrinol Metab 2000; 11:1-6.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Stroth U., Blume A., Mielke K., Unger T.h. Angiotensin AT2 receptor stimulates ERK1 and ERK2 in quiescent but inhibits ERK in NGF-stimulated PC12W cells. Brain Res Mol Brain Res 2000;78:175-80.[Medline]
[Order article via Infotrieve]
- Dimmeler S., Rippmann V., Weiland U., Haendeler J., Zeiher AM Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide. Circ Res 1997;81:970-6.[Abstract/Free Full Text]
- Gallinat S., Busche S., Schütze S., Krönke M., Unger T. AT2 receptor stimulation induces generation of ceramides in PC 12W cells. FEBS Lett 1999;433: 75-9.
- Lehtonen JY, Horiuchi M., Daviet L., Akishita M., Dzau V. Activation of de-novo biosynthesis of sphingolipids mediates angiotensin AT2 receptor-induced apoptosis. J Biol Chem 1999;274:16901-6.[Abstract/Free Full Text]
- Miura S., Karnik SS Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis. EMBO J 2000; 19:4026-35.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Tsutsumi K., Saavedra JM Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain. Am J Physiol 1991;261:667-70.
- Grady EF, Sechi LA, Griffin CA, Schambelan M., Kalinyak JE Expression of AT2 receptors in the developing rat fetus. J Clin Invest 1991;88(3):921-33.[Web of Science][Medline]
[Order article via Infotrieve]
- UngerTh, Chung O., Csikos T. et al. Angiotensin receptors. J Hypertens 1996;14(5)(Suppl):S95-S103.[CrossRef]
- Sayeski PP, Ali MS, Semeniuk DJ, Doan TN, Bernstein KE Angiotensin II signal transduction pathways. Regul Pept 1998;78:19-29.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Meffert S., Stoll M., Steckelings UM, Bottari SP, Unger Th.The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996;122(1):59-67.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Laflamme L., Gasparo M., Gallo JM, Payet MD, Gallo-Payet N. Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors. J Biol Chem 1996;271(37):22729-35.[Abstract/Free Full Text]
- Mesner PW, Epting CL, Hegarty JL, Green SH A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells. J Neurosci 1995; 15:7357-66.[Abstract]
- Stroth U., Meffert S., Gallinat S., Unger Th.Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor. Mol Brain Res 1998;53(1-2):187-95.[Medline]
[Order article via Infotrieve]
- Côté F., Do TH, Laflamme L., Gallo J.- M. Gallo- Payet N. Activation of the AT2 receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum. JBiol Chem 1999;274:31686-92.[Abstract/Free Full Text]
- HerdegenT, Skene P., Bähr M. The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 1997;20:227-31.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Kinloch RA,Treherne JM, Furness LM, Hajimohamadreza I. The pharmacology of apoptosis. TIPS 1999;20:35-42.[Medline]
[Order article via Infotrieve]
- Yamada T., Horiuchi M., Dzau VJ Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996;93(1):156-60.[Abstract/Free Full Text]
- Horiuchi M., Yamada T., Hayashida W., Kambe T., Yamada T., Dzau VJAngiotensin type2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 1997;272:19022-6.[Abstract/Free Full Text]
- Horiuchi M., Akishita M., Dzau VJ Molecular and cellular mechanism of angiotensin II-mediated apoptosis. Endocr Res 1998;24:307-14.[Web of Science][Medline]
[Order article via Infotrieve]
- Gallinat S., Csikos T., Meffert S., Herdegen T., Stoll M., Unger Th. The angiotensin AT2 receptor down-regulates neurofilament M in PC12W cells. Neurosci Lett 1997;227(1):29-32.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Hofmann K., Dixit VM Ceramide in apoptosis - does it really matter? TIBS 1998;23:374-7.[Medline]
[Order article via Infotrieve]
- Lucius R., Gallinat S., Rosenstiel P., Herdegen T., Sievers J., Unger T.h. The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. J Exp Med 1998;188:661-70.[Abstract/Free Full Text]
- Gallinat S.,Yu M., Dorst A., Unger T., Herdegen T. Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2 and AT1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves. Mol Brain Res 1998;57(1):111-22.[Medline]
[Order article via Infotrieve]
- Choi DW Ischemia-induced neural apoptosis. Curr Opinion Neurobiol 1996;6:667-72.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Dirnagl U., Iadecola C., Moskowitz MA Pathobiology of ischaemic stroke: an integrated view. TINS 1999;22:391-7.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- von Lutterotti N., Camargo MJ, Campbell WG Jr, Mueller FB, Timmermans PB, Sealey JE, Laragh JHAngiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats. J Hypertens 1992;10:949-57.[Web of Science][Medline]
[Order article via Infotrieve]
- Stier CT Jr, Adler LA, Levien S., Chandler PN Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats. J Hypertens 1993;11(3)(Suppl):S37-42.
- Werner C., Hoffman WE, Kochs E., Rabito SF, Miletich DJ Captopril improves neurologic outcome from incomplete cerebral ischemia in rats. Stroke 1991;22:910-4.[Abstract/Free Full Text]
- Sadoshima S., Fujii K., Ooboshi H., Ibayashi S., Fujishima M. Angiotensin converting enzyme inhibitors attenuate ischemic brain metabolism in hypertensive rats. Stroke 1993;24:1561-7.[Abstract/Free Full Text]
- Paulson OB, Waldemar G., Andersen AR et al. Role of angiotensin in autoregulation of cerebral blood flow. Circulation 1988;77(Suppl I):I-55-58.[Medline]
[Order article via Infotrieve]
- Inada Y., Wada T., Ojima M. et al. Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens1997;19:1079-99.
- Nishimura Y.,Takeshi I., Saavedra JM Angiotensin AT1 blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke 2000;31:2478-86.[Abstract/Free Full Text]
- Dai WJ, Funk A., Herdegen T., Unger T., Culman J. Blockade of central angiotensin AT1 receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats. Stroke 1999; 30:2391-9.[Web of Science][Medline]
[Order article via Infotrieve]
- Makino I., Shibata K., Ohgami Y., Fujiwara M., Furukawa T. Transient upregulation of the AT2 receptor mRNA level after global ischemia in the rat. Neuropeptides 1996;30:596-601.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Polidori C., Ciccocioppo R., Pompei P., Cirillo R., Massi M. Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain in rats. Eur J Pharmacol 1996;307:259-67.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Culman J., von Heyer C., Piepenburg B., Rascher W., Unger T. Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats. Eur J Pharmacol 1999;367:255-65.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Nishimura Y., Takeshi I., Hoe K.-L, Saavedra J.M. Chronic peripheral administration of the angiotensin AT1 receptor antagonist Candesartan blocks brain AT1 receptors. Brain Res 2000;871:29-38.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Gohlke P., Weiss S., Jansen A. et al. AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats. J Pharmacol Exp Ther 2001 (in print).
Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 2,
96-102 (2001)
DOI: 10.3317/jraas.2001.019

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