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Journal of Renin-Angiotensin-Aldosterone System
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Reviews

Review: Aldosterone-induced vasculopathy: a new reversible cause of cardiac death

Allan D Struthers

Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK, a.d.struthers@ dundee.ac.uk

Key Words: aldosterone • nitric oxide • fibrosis

References

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  • La Rovere MT, Bigger JT, Marcus FI, MortaraA, Sachwartz PJ for the ATRAMI Investigators.Baroreflex sensitivity and heart rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 1998;351:478-84.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Zuanetti G., Neilson JMM, Latini R., Santoro E., Maggioni AP, Ewing DJ on behalf of GISSI-2 investigators. Prognostic significance of heart rate variability in post myocardial infarction patients in the fibrinolytic era. The GISSI-2 results. Circulation 1996;94:432-6.[Abstract/Free Full Text]
  • Weber K., Brilla CG Pathological hypertrophy and cardiac interstitium: fibrosis and renin angiotensin aldosterone system. Circulation 1991;83:1849-65.[Abstract/Free Full Text]
  • Takeda Y., Miyamori I., Yoneda T. et al. Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin. J Clin Endocrinol Metab 1996;81(8):2797-800.[Abstract/Free Full Text]
  • Ideka U., Kanbe T., Nakayama I., Kawahara Y., Yokoyama M., Shimada K. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1. Eur J Pharmacol 1995;290:69-73.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Farquharson C., Struthers AD Spironolactone increases NO bioactivity, improves endothelial dysfunction and suppresses vascular AI/AII conversion in chronic heart failure. Circulation 2000;101:594-7.[Abstract/Free Full Text]
  • Duprez DA, de Buyzere ML, Reitzschel ER et al. Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients. Eur Heart J 1998;19:1371-6.[Abstract/Free Full Text]
  • Brown NJ, Kin KS, ChenYQ et al. Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production. J Clin Endocrinol Metab 2000;85:336-44.[Abstract/Free Full Text]
  • Rocha R., Chander PN, Zuckerman A., Stier CT Mineralocorticoid blockade reduces vascular injury in stroke prone hypertensive rats. Hypertension 1998;31[part 2]:451-8.[Abstract/Free Full Text]
  • Harada E.,Yoshimura M.,Yasul H. et al. Aldosterone induces ACE gene expression in cultured neonatal rat cardiocytes. Circulation 2001;104:137-9.[Abstract/Free Full Text]
  • Brilla CG, Matsubara LS, Weber KT Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronisin. J Mol Coll Cardiol 1993;25:563-75.[CrossRef]
  • Klappacher G., Franzen P., Haab D. et al. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol 1995;75:913-8.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Diez J., Laviadfes C., Mayor G., Gil MJ, Monreal I. Increased serum concentrations of procollagen peptides in essential hypertension. Circulation 1995;91:1450-6.[Abstract/Free Full Text]
  • MacFadyen RJ, Barr CS, Struthers AD.Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients. Cardiovasc Res 1997;35:30-4.[Abstract/Free Full Text]
  • Zannad F., Alla F., Dousset B. et al. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with CHF. Circulation 2000:102;2700-6.[Abstract/Free Full Text]
  • Pitt B., Zannad F., Remme WJ et al. The effect of spironolactone on mortality and morbidity in chronic heart failure. N Engl J Med 199;341:709-17.
  • Yee KM, Pringle SD, Struthers AD Circadian influence of aldosterone blockade on QT dispersion and heat rate variability in chronic heart failure. J Am Coll Cardiol 2001; 37:1800-7.[Abstract/Free Full Text]
  • Chowdhary S.,Townend JN Role of NO in the regulation of cardiovascular autonomic control. Clin Sci 1999;97:5-17.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Spiker LE, Corti R., Binggeli C. et al. Baroreceptor dysfunction induced by NO synthase inhibition in humans. J Am Coll Cardiol 2000;36:213-8.[Abstract/Free Full Text]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 2, No. 4, 211-214 (2001)
DOI: 10.3317/jraas.2001.033


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This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
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Right arrow Email this article to a friend
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Citing Articles
Right arrow Citing Articles via Google Scholar
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Right arrow Articles by Struthers, A. D
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PubMed
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Right arrow Articles by Struthers, A. D
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