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Interaction of ACE inhibitors and AT1-receptor blockers on maximum blood pressure response in spontaneous hypertensive rats

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia, t.morgan@ physiology.unimelb. edu.au

Cory Griffiths

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia

Lea Delbridge

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia

This study in spontaneous hypertensive rats (SHR) was designed to determine whether a greater fall in blood pressure (BP) could be achieved with the combination of an angiotensin-converting enzyme inhibitor (ACE-I) and an AT₁-receptor blocking drug than with higher doses of either drug alone.

The peak effect of captopril occurred 3—4 hours post-dose and a plateau response was achieved with 10 mg/kg. The peak effect of losartan occurred 7—8 hours post-dose and a plateau response was achieved with 10 mg/kg. Increasing the dose of either drug caused no greater fall in BP, but increased the duration of the effect.

Captopril, 10 mg/kg, administered with losartan 10 mg/kg caused a greater fall in BP than captopril or losartan, 20 mg/kg. This was present after acute doses or after one week of daily therapy.

The combination of ACE-I and AT₁-blocking drugs is more effective than either therapy alone and may be a useful combination to manage hypertension and/or cardiac failure.

Key Words: ACE inhibitors • AT1-receptor blockers • hypertension • SHR • telemetry • captopril • losartan

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 3, No. 1, 16-18 (2002)
DOI: 10.3317/jraas.2002.002


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Morgan, T. Articles by Delbridge, L. Search for Related Content PubMed PubMed Citation Articles by Morgan, T. Articles by Delbridge, L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CAPTOPRIL LOSARTAN POTASSIUM Medline Plus Health Information High Blood Pressure Social Bookmarking                         What's this?