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Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodelling after acute myocardial infarction in rats

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China, tyd211@ sina.com

Yida Tang

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Yingmao Ruan

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Yongli Li

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Yanwen Zhou

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Runlin Gao

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Jilin Chen

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Zaijia Chen

Cardiovascular Institute & Fu Wai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China

Objectives

To compare the effects of cilazapril, carvedilol and their combination in preventing left ventricular remodelling (LVRM) after acute myocardial infarction (AMI) in rats.

Methods

Twenty-four hours after left coronary artery ligation, 100 surviving AMI female Sprague-Dawley rats were randomly assigned to: (1) AMI control (n=25); (2) cilazapril (Cila, 1 mg/kg/day) (n=25); (3) carvedilol (Car, 1 mg/kg/day) (n=25), and (4) cilazapril (1 mg/kg/day)+ carvedilol (1 mg/kg/day) (combination) (n=25) groups. A sham-operated group (n=17) was selected randomly as a non-infarction control. After four weeks of therapy with the drugs given by gastric gavage, haemodynamic studies were performed, following which the rat hearts were fixed and pathologically analysed. Rats with MI size <35% or >55% were excluded. Complete data were obtained in 64 rats, comprising AMI control (n=13), Cila (n=12), Car (n=12), Combination (n=14), and sham-operated (n=13) groups.

Results

There were no significant differences in MI size between the four AMI groups (45.2—46.7%, p>0.05). Compared with the sham-operated group, left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), weight (LVW), septal thickness (STh) and right ventricular weight (RVW) were all significantly increased (all p<0.001) in the AMI group, while the LV pressure maximal rate of rise and fall (±dp/dt) was significantly decreased (all p<0.001). In comparison with the AMI group, LVEDP, LVV, LVW, STh and RVW were all significantly decreased, while ±dp/dt was significantly increased in the Cila, Car, and combination groups, with LVEDP and STh decreasing more in the combination group than in the two monotherapy groups (p<0.05—0.01). There were no significant differences in other variables between the three therapy groups.

Conclusions

Cilazapril, carvedilol and their combination are all effective in preventing LVRM after AMI in rats, and in improving haemodynamics and LV function, with the combination therapy being superior to monotherapy in all respects.

Key Words: cilazapril • carvedilol • acute myocardial infarction • left ventricular remodelling • rat

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 3, No. 1, 31-35 (2002)
DOI: 10.3317/jraas.2002.005


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yuejin Yang Articles by Zaijia Chen Search for Related Content PubMed PubMed Citation Articles by Yuejin Yang, Articles by Zaijia Chen, Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CARVEDILOL Medline Plus Health Information Heart Attack Social Bookmarking                         What's this?