|
Sign In to gain access to subscriptions and/or personal tools.
|
Lack of rapid aldosterone effects on forearm resistance vasculature in health
Prasad Gunaruwan
Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK, gunaruwanpt@ cardiff.ac.uk
Matthias Schmitt
Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
Justin Taylor
Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
Leong Lee
Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
Allan Struthers
University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Michael Frenneaux
Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
Objectives
Systemic infusions of aldosterone cause an acute increase in systemic vascular resistance (SVR) in healthy subjects. It is not clear whether this is due to a direct effect on the vasculature or the result of increased sympathetic tone. We investigated the short-term effects of locally infused aldosterone on the forearm resistance bed.
Methods
In this dose response study, we assessed the effects of incremental doses (10, 50, 100 ng/minute) of intrabrachial aldosterone on forearm blood flow (FBF), using conventional strain gauge plethysmography. Arterial blood pressure was monitored continuously, using finger photo-plethysmography. Forearm vascular resistance (FVR) was calculated. FBF and FVR were also measured in the non-infused arm. Changes in FBF and FVR in the infused arm were corrected for those occurring in the control arm.
Results
Plasma aldosterone levels in the venous effluent of the infused arm increased in a dose-dependent fashion, from 113.3±17.9 pg/ml at baseline to 297.8±51.8 pg/ml at 10 ng/minute (p=<0.01), 743.9±105.9 pg/ml at 50 ng/min (p=<0.001 vs. baseline) and 1230.6±73.7 pg/ml at 100 ng/min (p=<0.0005 vs. baseline). Plasma concentrations of aldosterone in the control arm did not change significantly vs. baseline. The corrected FBF (+4.1±10.3%) and corrected FVR (+4.3±11.3%) did not change significantly even at peak infusion rates.
Conclusions
Local intra-arterial infusion of aldosterone had no acute effect on forearm resistance vessels in healthy male volunteers.
Key Words: aldosterone • forearm vascular resistance
References
- Brilla CG Aldosterone and myocardial fibrosis in heart failure. Herz 2000;25:299-306.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Brilla CG Renin-angiotensin-aldosterone system and myocardial fibrosis. Cardiovasc Res 2000;47:1-3.[Free Full Text]
- Ramires FJ, Sun Y., Weber KT Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade.JMol Cell Cardiol 1998;30:475-83.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Sun Y., Ramires FJ, Weber KT Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion. Cardiovasc Res 1997;35:138-47.[Abstract/Free Full Text]
- Brilla CG, Maisch B. Regulation of the structural remodelling of the myocardium: from hypertrophy to heart failure. Eur Heart J 1994;15(suppl D):45-52.[Abstract/Free Full Text]
- Weber KT, Brilla CG, Campbell SE, Guarda E., Zhou G., Sriram K. Myocardial fibrosis: role of angiotensin II and aldosterone. Basic Res Cardiol 1993;88(suppl 1):107-24.[Web of Science][Medline]
[Order article via Infotrieve]
- Brilla CG, Weber KT Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 1992;120:893-901.[Web of Science][Medline]
[Order article via Infotrieve]
- Brilla CG, Maisch B.,Weber KT Myocardial collagen matrix remodelling in arterial hypertension. Eur Heart J 1992;13 (suppl D):24-32.[Abstract]
- Weber KT, Brilla CG Myocardial fibrosis and the renin-angiotensin-aldosterone system. J Cardiovasc Pharmacol 1992;20(suppl 1):S48-S54.
- Weber KT, Brilla CG, Campbell SE, Zhou G., Matsubara L., Guarda E. Pathological hypertrophy with fibrosis: the structural basis for myocardial failure. Blood Press 1992;1:75-85.[Medline]
[Order article via Infotrieve]
- Weber KT, Brilla CG Pathological hypertrophy and cardiac interstitium. Fibrosis and renin- angiotensin-aldosterone system. Circulation 1991;83:1849-65.[Abstract/Free Full Text]
- Duprez DA, De Buyzere ML, Reitzschel ER et al. Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients. Eur Heart J 1998; 19(9):1371-6.[Abstract/Free Full Text]
- Wehling M., Spes CH, Win N. et al. Rapid cardiovascular actions of aldosterone in man. J Clin Endocrinol Metab 1998;83:3517-22.[Abstract/Free Full Text]
- Schmidt BMW, Montealegre A., Janson CP et al. Short term cardiovascular effects of aldosterone in healthy male volunteers. J Clin Endocrinol Metab 1999;84:3528-33.[Abstract/Free Full Text]
- Yee KM, Struthers AD Aldosterone blunts the baroreflex response in man. Clin Sci 1998;95:687-92.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Booth RE, Johnson JP, Stockland JD Aldosterone. Adv Physiol Educ 2002;26:8-20.[Abstract/Free Full Text]
- Young M., Funder JW Aldosterone and the heart. Trends Endocrinol Metab 2000;11(6):224-6.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Funder J. Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance. Ann Rev Med 1997;48:231-40.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Christ M., Douwes K., Eisen C., Bechtner G., Theisen K., Wehling M. Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells. Hypertension 1995;25(1):117-23.[Abstract/Free Full Text]
- Ebata S., Muto S., Okada K. et al.Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by non genomic and genomic mechanisms. Kidney Int 1999;56:1400-12.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Christ M., Gunter A., Heck M., Schmidt BMW, Frankenstein E., Wehling M. Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. Circulation 1999;99:1485-91.[Abstract/Free Full Text]
- Wehling M., Neylon CB, Fullerton M., Bobik A., Funder JW Non genomic effects of aldosterone on intracellular Ca2+ in vascular smooth muscle cell. Circ Res 1995;76:973-9.[Abstract/Free Full Text]
- Schmidt BMW, Geogeans A., Martin N. et al. Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system. J Clin Endocrinol Metab 2001;86:761-7. 24. Struthers AD Impact of aldosterone on vascular pathophysiology. Congest Heart Fail 2002;8:18-22.[Medline]
[Order article via Infotrieve]
- Wang W., McClain JM, Zucker IH Aldosterone reduces baroreceptor discharge in the dog. Hypertension 1992; 19(3):270-7.[Abstract/Free Full Text]
Journal of Renin-Angiotensin-Aldosterone System, Vol. 3, No. 2,
123-125 (2002)
DOI: 10.3317/jraas.2002.013
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
A. R. Maher, A. B. Milsom, P. Gunaruwan, K. Abozguia, I. Ahmed, R. A. Weaver, P. Thomas, H. Ashrafian, G. V.R. Born, P. E. James, et al.
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
Circulation,
February 5, 2008;
117(5):
670 - 677.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Nietlispach, B. Julius, R. Schindler, A. Bernheim, C. Binkert, W. Kiowski, and H. P. Brunner-La Rocca
Influence of Acute and Chronic Mineralocorticoid Excess on Endothelial Function in Healthy Men
Hypertension,
July 1, 2007;
50(1):
82 - 88.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Ponda and T. H. Hostetter
Aldosterone Antagonism in Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol.,
July 1, 2006;
1(4):
668 - 677.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M.W. Schmidt and R. E. Schmieder
Letters to the Editor: Response
Hypertension,
January 1, 2004;
e2(1):
.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schmitt, P. Gunaruwan, and M. P. Frenneaux
Letters to the Editor: Rapid Nongenomic Aldosterone Effects in the Human Forearm?
Hypertension,
January 1, 2004;
e1(1):
.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. Liu, S. Schmuck, J. Z. Chorazcyzewski, R. Gros, and R. D. Feldman
Aldosterone Regulates Vascular Reactivity: Short-Term Effects Mediated by Phosphatidylinositol 3-Kinase-Dependent Nitric Oxide Synthase Activation
Circulation,
November 11, 2003;
108(19):
2400 - 2406.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schmitt, A. J.M. Broadley, A. K. Nightingale, N. Payne, P. Gunaruwan, J. Taylor, L. Lee, J. Cockcroft, A. D. Struthers, and M. P. Frenneaux
Atrial Natriuretic Peptide Regulates Regional Vascular Volume and Venous Tone in Humans
Arterioscler Thromb Vasc Biol,
October 1, 2003;
23(10):
1833 - 1838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
