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Renal graft failure after addition of an angiotensin II receptor antagonist to an angiotensin-converting enzyme inhibitor: unmasking of an unknown iliac artery stenosis

Department of Nephrology, Herlev Hospital, ankam@ herlevhosp.kbhamt.dk

Arne Høj Nielsen

Department of Nephrology, Herlev Hospital

Niels Bækgaard

Department of Vascular Surgery, University of Copenhagen

Svend Just

Department of Radiology, Gentofte Hospital, University of Copenhagen, Denmark

Combined treatment with an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II (Ang II) receptor blocker (ARB) has been suggested in order to achieve a more complete blockade of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. The present report describes a case of acute renal graft dysfunction following the addition of an ARB to existing ACE inhibition. This unmasked an unknown iliac artery stenosis. The case indicates a possible important role of Ang II generated by non-ACE pathways in this situation.

Key Words: dual angiotensin II blockade • renal artery stenosis • renal graft dysfunction

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 3, No. 2, 135-137 (2002)
DOI: 10.3317/jraas.2002.016


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kamper, A.-L. Articles by Just, S. Search for Related Content PubMed PubMed Citation Articles by Kamper, A.-L. Articles by Just, S. Pubmed/NCBI databases Medline Plus Health Information Kidney Transplantation Social Bookmarking                         What's this?