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Journal of Renin-Angiotensin-Aldosterone System
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Review: Salt, blood pressure and the renin-angiotensin system

Feng J He

Blood Pressure Unit, St George's Hospital Medical School, London, SW17 0RE, UK

Graham A MacGregor

Blood Pressure Unit, St George's Hospital Medical School, London, SW17 0RE, UK, g.macgregor@ sghms.ac.uk

Much evidence from epidemiological, migration, intervention, animal and genetic studies suggests that salt intake plays an important role in regulating blood pressure (BP). At the same time, many clinical trials have shown that reducing salt intake lowers BP. However, the magnitude of the fall in BP for a given reduction in salt intake varies with age, ethnic group and BP levels. This difference has been suggested to be related to the responsiveness of the renin-angiotensin system (RAS). However, the sympathetic nervous system, the kallikrein-kinin system, the nitric oxide system, and many eicosanoids may also play a role. In this article, we address the important role of the RAS in determining the fall in BP with salt reduction.

Key Words: salt intake • blood pressure • renin-angiotensin system

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 4, No. 1, 11-16 (2003)
DOI: 10.3317/jraas.2003.001
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This Article
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