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Journal of Renin-Angiotensin-Aldosterone System
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Review: Early renal involvement in Type 1 diabetes mellitus — Part 2: ACE inhibitor intervention in Type 1 diabetes with low grade microalbuminuria

Løgstrup Poulsen

Medical Department M (Diabetes & Endocrinology), Aarhus Kommunehospital, DK-8000 Aarhus C, Denmark, perlogstrup{at}mail.dk

Several clinical trials have consistently shown that antihypertensive treatment, particularly with angiotensin-converting enzyme inhibitors (ACE-I) reduces albuminuria in Type 1 diabetic patients. More recently, data on the beneficial effects of ACE-I on the preservation of glomerular filtration rate and renal ultrastructure have emerged. However, in general, these trials have recruited a wide spectrum of diabetics, including some patients with severe albuminuria. Thus, the question of the ideal stage at which to instigate what is likely to be lifelong therapy in young people still remains unanswered.

Exercise is known to significantly increase both blood pressure (BP) and urinary albumin excretion (UAE), both of which are important determinants of progression of nephropathy in diabetes. Thus, it is possible that exercise may have an adverse effect on diabetic renal disease. The effects of ACE-I on exercise-BP and exercise-UAE in microalbuminuric Type 1 diabetic patients has not been examined in long-term placebo-controlled studies.

In the second part of this two-part review, we examine the effects of the ACE-I, lisinopril, 20 mg o.d. for two years, in comparison with placebo, on UAE, 24-hour ambulatory BP, exercise-BP, exercise-UAE and renal haemodynamics in 22 patients with Type 1 diabetes and low-grade microalbuminuria. We further discuss the effects of ACE-I on nephropathy and other complications of diabetes.

Key Words: angiotensin-converting enzyme inhibitors • diabetes • nephropathy • microalbuminuria • 24-hour ambulatory blood pressure

References

  • Andersen AR, Christiansen JS, Andersen JK, Kreiner S., Deckert T. Diabetic nephropathy in Type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia 1983;25:496-501.[Web of Science][Medline] [Order article via Infotrieve]
  • Krolewski AS, Warram JH, Christlieb AR The changing natural history of nephropathy in type I diabetes. Am J Med 1985;78:785-94.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Kofoed Enevoldsen A., Borch-Johnsen K., Kreiner S., Nerup J., Deckert T. Declining incidence of persistent proteinuria in type 1 (insulin-dependent) diabetic patients in Denmark. Diabetes 1987;36:205-09.[Abstract]
  • Rossing P., Rossing K., Jacobsen P., Parving H-H. Unchanged incidence of diabetic nephropathy in IDDM patients. Diabetes 1995;44:739-43.[Abstract]
  • Wang PH, Lau J., Chalmers TC Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes. Lancet 1993;341:1306-09.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Tarnow L., Cambien F., Rossing P. et al. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes 1995;44:489-94.[Abstract]
  • Viberti GC, Hill RD, Jarrett RJ,Argyropoulos A., Mahmud U., Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1982; I:1430-2.
  • Parving H-H., Oxenboll B., Johansen K., Svendsen PA, Christiansen JS, Andersen AR Early detection of patients at risk of developing diabetic nephropathy: a longitudinal study of 100:500-05. urinary albumin excretion. Acta Endocrinol Copenh 1982;
  • Mogensen CE, Christensen CK Predicting diabetic nephropathy in insulin-dependent patients. N Engl JMed 1984;311:89-93.[Abstract]
  • Mathiesen ER, Oxenboll B., Johansen K., Svendsen PA, Deckert T. Incipient nephropathy in type 1 (insulin-dependent) diabetes. Diabetologia 1984;26:406-10.[Web of Science][Medline] [Order article via Infotrieve]
  • Mogensen CE Microalbuminuria, blood pressure and diabetic renal disease: origin and development of ideas. Diabetologia 1999;42:263-85.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wiseman M., Viberti G., Mackintosh D., Jarrett RJ, Keen H. Glycaemia, arterial pressure and micro-albuminuria in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1984; 26:401-05.[Web of Science][Medline] [Order article via Infotrieve]
  • Feldt Rasmussen B., Borch-Johnsen K., Mathiesen ER Hypertension in diabetes as related to nephropathy. Early blood pressure changes. Hypertension 1985;7:1118-1120.
  • Hansen KW, Christensen CK,Andersen PH, Pedersen MM, Christiansen JS, Mogensen CE Ambulatory blood pressure in microalbuminuric type 1 diabetic patients. Kidney Int 1992;41:847-54.[Web of Science][Medline] [Order article via Infotrieve]
  • Hansen KW, Mau Pedersen M., Marshall SM, Christiansen JS, Mogensen CE Circadian variation of blood pressure in patients with diabetic nephropathy. Diabetologia 1992; 35:1074-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Moore WV, Donaldson DL, ChonkoAM, Ideus P.,Wiegmann TB Ambulatory blood pressure in type I diabetes mellitus. Comparison to presence of incipient nephropathy in adolescents and young adults. Diabetes 1992;41:1035-41.[Abstract]
  • Benhamou PY, Halimi S., De Gaudemaris R. et al. Early disturbances of ambulatory blood pressure load in normotensive type I diabetic patients with microalbuminuria. Diabetes Care 1992;15:1614-19.[Abstract]
  • Berrut G., Hallab M., Bouhanick B., Chameau AM, Marre M., Fressinaud P. Value of ambulatory blood pressure monitoring in Type I (Insulin-Dependent) diabetic patients with incipient diabetic nephropathy.AmJHypertens 1994;7:222-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Poulsen PL, Ebbehøj E., Hansen KW, Mogensen CE Elevated ambulatory blood pressure in microalbuminuric IDDM patients is inversely related with renal plasma flow - a compensatory mechanism? Diabetes Care 1997;20:429-32.[Abstract]
  • Marre M., Chatellier G., Leblanc H., Guyene TT, Menard J., Passa P. Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria. BMJ 1988; 297:1092-5.[Abstract/Free Full Text]
  • Rudberg S., Aperia A., Freyschuss U., Persson B. Enalapril reduces microalbuminuria in young normotensive type 1 (insulin-dependent) diabetic patients irrespective of its hypotensive effect. Diabetologia 1990;33:470-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Mathiesen ER, Hommel E., Giese J., Parving H-H. Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ 1991;303:81-7.[Abstract/Free Full Text]
  • Viberti G., Mogensen CE, Groop LC, Pauls JF Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group. JAMA 1994;271:275-9.[Abstract/Free Full Text]
  • The EUCLID Study Group: Randomised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuria. Lancet 1997;349:1787-92.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Mathiesen ER, Hommel E., Hansen HP, Smidt UM, Parving H-H. Randomised controlled trial of long term efficacy of captopril on preservation of kidney function in normotensive patients with insulin dependent diabetes and microalbuminuria. BMJ 1999;319:24-5.[Free Full Text]
  • Rudberg S., sterby R., Bangstad HJ, Dahlquist G., Persson B. Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus. Diabetologia 1999;42:589-95.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hovind P., Rossing P., Tarnow L., Smidt UM, Parving H-H. Progression of diabetic nephropathy. Kidney Int 2001;59:702-09.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Microalbuminuria Collaborative Study Group, UK: Risk factors for development of microalbuminuria in insulin dependent diabetic patients: a cohort study. BMJ 1993;306:1235-9.[Abstract/Free Full Text]
  • Poulsen PL, Hansen KW, Mogensen CE Ambulatory blood pressure in the transition from normo- to microalbuminuria.A longitudinal study in IDDM patients. Diabetes 1994;43:1248-53.[Abstract]
  • Mathiesen ER, Ronn B., Storm B., Foght H., Deckert T. The natural course of microalbuminuria in insulin-dependent diabetes: a 10-year prospective study. Diabet Med 1995;12:482-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Voros P., Lengyel Z., Nagy V.,Nemeth C., Rosivall L., Kammerer L. Diurnal blood pressure variation and albuminuria in normotensive patients with insulin-dependent diabetes mellitus. Nephrol Dial Transplant 1998;13:2257-60.[Abstract/Free Full Text]
  • Mølgaard H., Christensen PD, Sørensen KE, Christensen CK, Mogensen CE Association of 24-h cardiac parasympathetic activity and degree of nephropathy in IDDM patients. A Diabetes 1992;41:812-17.[CrossRef]
  • Mølgaard H., Christensen PD, Hermansen K., Sørensen KE, Christensen CK, Mogensen CE Early recognition of autonomic dysfunction in microalbuminuria: significance for cardiovascular mortality in diabetes mellitus? Diabetologia 1994;37:78896.
  • Jensen T., Stender S., Deckert T. Abnormalities in plasmas concentrations of lipoproteins and fibrinogen in type 1 (insulin-dependent) diabetic patients with increased urinary albumin excretion. Diabetologia 1988;31:142-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jones SL, Close CF, Mattock MB, Jarrett RJ, Keen H., Viberti GC Plasma lipid and coagulation factor concentrations in insulin dependent diabetics with microalbuminuria. BMJ 1989; 298:487-90.[Abstract/Free Full Text]
  • Jensen T., Bjerre Knudsen J., Feldt Rasmussen B., Deckert T. thy. Lancet 1989;1:461-3. Features of endothelial dysfunction in early diabetic nephropa[Web of Science][Medline] [Order article via Infotrieve]
  • Stehouwer CD, Stroes ES, Hackeng WH, Mulder PG, den Ottolander GJ von Willebrand factor and development of diabetic nephropathy in IDDM [published erratum appears in Diabetes 1991 Dec;40(12):1746.] Diabetes 1991;40:971-6.[Abstract]
  • Dogra G., Rich L., Stanton K., Watts GF Endothelium-dependent and independent vasodilation studies at normoglycaemia in type I diabetes mellitus with and without microalbuminuria. Diabetologia 2001;44:593-601.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Parving H-H., Hommel E., Mathiesen E. et al. Prevalence of microalbuminuria, arterial hypertension, retinopathy and neuropathy in patients with insulin dependent diabetes. BMJ 1988;296:156-60.[Abstract/Free Full Text]
  • Chavers BM, Mauer SM, Ramsay RC, Steffes MW Relationship between retinal and glomerular lesions in IDDM patients. Diabetes 1994;43:441-6.[Abstract]
  • Ekbom P., Damm P., Nogaard K. et al. Urinary albumin excretion and 24-hour blood pressure as predictors of pre-eclampsia in Type I diabetes.Diabetologia 2000;43:927-31.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Bangstad HJ, sterby R., Dahl Jorgensen K. et al. Early glomerulopathy is present in young, Type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 1993;36:523-9.[Web of Science][Medline] [Order article via Infotrieve]
  • sterby R., Bangstad HJ, Nyberg G.,Walker JD,Viberti GC A quantitative ultrastructural study of juxtaglomerular arterioles in IDDM patients with micro- and normoalbuminuria. Diabetologia 1995;38:1320-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Jensen JS, Feldt-Rasmussen B., Strandgaard S., Schroll M., Borch-Johnsen K. Arterial hypertension, microalbuminuria, and risk of ischemic heart disease. Hypertension 2000;35:898-903.[Abstract/Free Full Text]
  • Kasiske BL, Kalil RS, Ma JZ, Liao M., Keane WF Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Ann Intern Med 1993; 118:129-38.[Abstract/Free Full Text]
  • Poulsen PL Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes. JRAAS 2002;3:222-42.[Medline] [Order article via Infotrieve]
  • Mogensen CE, Keane WF, Bennett PH et al. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet 1995;346:1080-4.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Cooper ME Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet 1998;352:213-19.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pedersen MM, Schmitz A., Pedersen EB, Danielsen H., Christiansen JS Acute and long-term renal effects of angiotensin converting enzyme inhibition in normotensive, normoalbuminuric insulin-dependent diabetic patients. Diabet Med 1988;5:562-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Kvetny J., Gregersen G., Pedersen R. Randomized placebo-controlled trial of perindopril in normotensive, normoalbuminuric patients with type 1 diabetes mellitus. QJM 2001;94:89-94.[Abstract/Free Full Text]
  • Mogensen CE, Hansen KW, sterby R., Damsgaard EM Blood pressure elevation versus abnormal albuminuria in the genesis and prediction of renal disease in diabetes. Diabetes Care 1992;15:1192-204.[Abstract]
  • Hansen KW, Klein F., Christensen PD et al. Effects of captopril on ambulatory blood pressure, renal and cardiac function in microalbuminuric type 1 diabetic patients. Diabet Metab 1994;20:485-93.[Web of Science][Medline] [Order article via Infotrieve]
  • Karlefors T. Haemodynamic studies in male diabetics. Acta Med Scand 1966;449(suppl):45-80.
  • Mogensen CE, Vittinghus E., Sølling K. Abnormal albumin excretion after two provocative renal tests in diabetes: physical exercise and lysine injection. Kidney Int 1979;16:385-93.[Web of Science][Medline] [Order article via Infotrieve]
  • Vittinghus E., Mogensen CE Graded exercise and protein excretion in diabetic man and the effect of insulin treatment. Kidney Int 1982;21:725-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Christensen CK Abnormal albuminuria and blood pressure rise in incipient diabetic nephropathy induced by exercise. Kidney Int 1984;25:819-23.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Rossing P., Hommel E., Smidt UM, Parving H-H. Impact of arterial blood pressure and albuminuria on the progression of diabetic nephropathy in IDDM patients. Diabetes 1993;42:71519.
  • Watkins PJ, Blainey JD, Brewer DB et al.The natural history of diabetic renal disease. QJM 1972;41:437-56.[Abstract/Free Full Text]
  • Parving H-H., Rossing P., Hommel E., Smidt UM Angiotensin-converting enzyme inhibition in diabetic nephropathy: ten years' experience. Am J Kidney Dis 1995;26:99-107.[Web of Science][Medline] [Order article via Infotrieve]
  • Remuzzi G., Bertani T. Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules? Kidney Int 1990;38:384-94.[Web of Science][Medline] [Order article via Infotrieve]
  • Hebert LA, Agarwal G., Sedmak DD, Mahan JD, Becker W., Nagaraja HN Proximal tubular epithelial hyperplasia in patients with chronic glomerular proteinuria. Kidney Int 2000;57:1962-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Koivisto VA, Huttunen NP, Vierikko P. Continuous subcutaneous insulin infusion corrects exercise-induced albuminuria in juvenile diabetes. BMJ 1981;282:778-9.[Free Full Text]
  • Viberti G., Pickup JC, Bilous RW, Keen H., Mackintosh D. Correction of exercise-induced microalbuminuria in insulin-dependent diabetics after 3 weeks of subcutaneous insulin infusion. Diabetes 1981;30:818-23.[Medline] [Order article via Infotrieve]
  • Mogensen CE, Christensen CK,Vittinghus E. The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy. Diabetes 1983;32(suppl 2):64-78.[Web of Science][Medline] [Order article via Infotrieve]
  • Poulsen PL, Ebbehøj E., Nosadini R., Crepaldi G., Mogensen CE Early ACE-I intervention in microalbuminuric patients with type 1 diabetes: Effects on albumin excretion, 24 h ambulatory blood pressure, and renal function. Diabet Metab 2001;27:123-8.[Web of Science][Medline] [Order article via Infotrieve]
  • Crepaldi G., Carta Q., Deferrari G. et al. Effects of lisinopril and nifedipine on the progression to overt albuminuria in IDDM patients with incipient nephropathy and normal blood pressure. The Italian Microalbuminuria Study Group in IDDM. Diabetes Care 1998;21:104-10.[Abstract]
  • Poulsen PL, Ebbehøj E., Mogensen CE Lisinopril reduces albuminuria during exercise in low grade microalbuminuric Type 1 diabetic patients: A double blind randomized study. J Intern Med 2001;249(5):433-40.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hansen KW, Poulsen PL, Mogensen CE Ambulatory blood pressure and abnormal albuminuria in type 1 diabetic patients. Kidney Int 1994;45(suppl):S134-S140.[Web of Science]
  • Hansen KW, Poulsen PL, Christiansen JS, Mogensen CE Determinants of 24-h blood pressure in IDDM patients. Diabetes Care 1995;18:529-35.[Abstract]
  • Mogensen CE Glomerular filtration rate and renal plasma flow in short-term and long-term juvenile diabetes mellitus. Scand J Clin Lab Invest 1971;28:91-100.[Web of Science][Medline] [Order article via Infotrieve]
  • Hansen KW, Mau Pedersen M., Christensen CK, Schmitz A., Christiansen JS, Mogensen CE Normoalbuminuria ensures no reduction of renal function in type 1 (insulin-dependent) diabetic patients.J Intern Med 1992;232:161-7.[Web of Science][Medline] [Order article via Infotrieve]
  • Mogensen CE, Hansen KW, Nielsen S., Pedersen MM, Rehling M., Schmitz A. Monitoring diabetic nephropathy: Glomerular filtration rate and abnormal albuminuria in diabetic renal disease - reproduceability, progression and efficacy of antihypertensive intervention. Am J Kidney Dis 1993;22:174-87.[Web of Science][Medline] [Order article via Infotrieve]
  • Zatz R., Dunn BR, Meyer TW, Anderson S., Rennke HG, Brenner BM Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest 1986;77:1925-30.[Web of Science][Medline] [Order article via Infotrieve]
  • Imanishi M.,Yoshioka K., Konishi Y. et al. Glomerular hypertension as one cause of albuminuria in type II diabetic patients. Diabetologia 1999;42:999-1005.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Christiansen JS On the pathogenesis of the increased glomerular filtration rate in short-term insulin-dependent diabetes. Dan Med Bull 1984;31:349-61.[Web of Science][Medline] [Order article via Infotrieve]
  • Parving H-H., Hommel E., Smidt UM Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy. BMJ 1988;297:1086-91.[Abstract/Free Full Text]
  • Elving LD, Wetzels JF, de Nobel E., Hoitsma AJ, Berden JH Captopril acutely lowers albuminuria in normotensive patients with diabetic nephropathy. Am J Kidney Dis 1992;20:559-63.[Web of Science][Medline] [Order article via Infotrieve]
  • Feldt Rasmussen B., Baker L., Deckert T. Exercise as a provocative test in early renal disease in type 1 (insulin-dependent) diabetes: albuminuric, systemic and renal haemodynamic responses. Diabetologia 1985;28:389-96.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Romanelli G., Giustina A., Cimino A. et al. Short term effect of captopril on microalbuminuria induced by exercise in normotensive diabetics. BMJ 1989;298:284-8.[Abstract/Free Full Text]
  • Romanelli G., Giustina A., Bossoni S. et al. Short-term administration of captopril and nifedipine and exercise-induced albuminuria in normotensive diabetic patients with early-stage nephropathy. Diabetes 1990;39:1333-8.[Abstract]
  • Christensen CK, Mogensen CE Acute and long-term effect of antihypertensive treatment on exercise-induced albuminuria in incipient diabetic nephropathy. Scand J Clin Lab Invest 1986;46:553-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Tuominen JA, Ebeling P., Koivisto VA. Long-term lisinopril therapy reduces exercise-induced albuminuria in normoalbuminuric normotensive IDDM patients. Diabetes Care 1998;21:1345-8.[Abstract]
  • Rossing P., Hougaard P., Borch-Johnsen K., Parving H-H. Predictors of mortality in insulin dependent diabetes: 10 year observational follow up study. BMJ 1996;313:779-84.[Abstract/Free Full Text]
  • Messent JW, Elliott TG, Hill RD, Jarrett RJ, Keen H., Viberti GC Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: a twenty-three year follow-up study. Kidney Int 1992;41:836-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Caramori ML, Fioretto P., Mauer M. The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient? Diabetes 2000;49:1399-408.[Abstract]
  • Fioretto P., Steffes MW, Mauer M. Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria. Diabetes 1994;43:1358-64.[Abstract]
  • Forsblom CM, Groop PH, EkstrandA, Groop LC Predictive value of microalbuminuria in patients with insulin-dependent diabetes of long duration. BMJ 1992;305:1051-3.[Abstract/Free Full Text]
  • Rossing P., Hougaard P., Borch-Johnsen K., Parving H-H. Progression from microalbuminuria to diabetic nephropathy in IDDM. J Am Soc Nephrol 1997;8:(abstract).
  • Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria. The Microalbuminuria Captopril Study Group. Diabetologia 1996;39:587-93.[Medline] [Order article via Infotrieve]
  • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N Engl J Med 2000;342:381-9.[Abstract/Free Full Text]
  • sterby R. Glomerular structural changes in type 1 (insulin-dependent) diabetes mellitus: causes, consequences, and prevention. Diabetologia 1992;35:803-12.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Franken AA, Derkx FH, Blankestijn PJ et al. Plasma prorenin as an early marker of microvascular disease in patients with diabetes mellitus. Diabet Metab 1992;18:137-43.[Web of Science][Medline] [Order article via Infotrieve]
  • Daneman D., Crompton CH, Balfe JW et al. Plasma prorenin as an early marker of nephropathy in diabetic (IDDM) adolescents. Kidney Int 1994;46:1154-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Allen,TJ, Cooper ME, Gilbert RE,Winikoff J., Skinni SL, Jerums G. Serum total renin is increased before microalbuminuria in diabetes. Kidney Int 1996;50:902-07.[Web of Science][Medline] [Order article via Infotrieve]
  • Deinum J., Ronn B., Mathiesen E., Derkx FH, Hop WC, Schalekamp MA Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologia 1999;42:1006-10.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jensen T. Increased plasma concentration of von Willebrand factor in insulin dependent diabetics with incipient nephropathy. BMJ 1989;298:27-8.[Free Full Text]
  • Coonrod BA, Ellis D., Becker DJ et al. Predictors of Microalbuminuria in Individuals with IDDM. Pittsburg Epidemiology of Diabetes Complication Study. Diabetes Care 1993;16:1376-83.[Abstract]
  • Chaturvedi N., Bandinelli S., Mangili R., Penno G., Rottiers R., Fuller JH Microalbuminuria in type 1 diabetes: rates, risk factors and glycemic threshold. Kidney Int 2001;60:219-27.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Watts GF, Powrie JK, O'Brien SF, Shaw KM Apolipoprotein B independently predicts progression of very-low-level albuminuria in insulin-dependent diabetes mellitus. Metabolism 1996;45:1101-07.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Moorhead JF, Chan MK, El Nahas M., Varghese Z. Lipid nephrotoxicity in chronic progressive glomerular and tubulointerstitial disease. Lancet 1982;2:1309-11.[Web of Science][Medline] [Order article via Infotrieve]
  • Bojestig M., Karlberg B., Lindström T., Nystrom F. Reduction of ACE activity is insufficient to decrease microalbuminuria in normotensive patients with type 1 diabetes. Diabetes Care 2001;24(5):919-24.[Abstract/Free Full Text]
  • The ATLANTIS Study Group. Low-dose ramipril reduces microalbuminuria in type 1 diabetic patients without hypertension: results of a randomized controlled trial. Diabetes Care 2000;23:1823-9.[Abstract/Free Full Text]
  • Effect of 3 years of antihypertensive therapy on renal structure in type 1 diabetic patients with albuminuria: the European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT). Diabetes 2001;50:843-50.[Abstract/Free Full Text]
  • Heart Outcomes Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 2000;355:253-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hansson L., Lindholm LH, Niskanen L. et al. Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 1999;353:611-16.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jensen T. The HOPE study and diabetes. Heart Outcomes Prevention Evaluation. Lancet 2000;355:1181-4.[Medline] [Order article via Infotrieve]
  • Chaturvedi N., Sjolie AK, Stephenson JM et al. Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes.The EUCLID Study Group. EURO-DIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus.Lancet 1998;351:28-31.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Chase HP, Satish K., Harris S., Hoops S., Jackson WE, Holmes DL Angiotensin-converting enzyme inhibitor treatment for young normotensive diabetic subjects: A two-year trial. Ann Ophthalmol 1993;25:284-9.[Web of Science][Medline] [Order article via Infotrieve]
  • Larsen M., Hommel E., Parving H-H., Lund-Andersen H. Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy. Graefes Arch Clin Exp Ophthalmol 1990;228:505-09.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jackson WE, Holmes DL, Garg SK, Harris S., Chase HP Angiotensin-converting enzyme inhibitor therapy and diabetic retinopathy. Ann Ophthalmol 1992;24:99-103.[Web of Science][Medline] [Order article via Infotrieve]
  • UKPDS 38. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: [published erratum appears in BMJ 1999 Jan 2;318(7175):29]. BMJ 1998; 317:703-13.[Abstract/Free Full Text]
  • UKPDS 39. UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes. BMJ 1998;317:713-20.[Abstract/Free Full Text]
  • Forrest KY, Maser RE, Pambianco G., Becker DJ, Orchard TJ Hypertension as a risk factor for diabetic neuropathy: a prospective study. Diabetes 1997;46:665-70.[Abstract]
  • Reja A., Tesfaye S., Harris ND, Ward JD Is ACE inhibition with lisinopril helpful in diabetic neuropathy? Diabet Med 1995;12:307-09.[Web of Science][Medline] [Order article via Infotrieve]
  • Malik RA, Williamson S., Abbott C. et al. Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double-blind controlled trial. Lancet 1998; 352:1978-81.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Moore MV, Jeffcoate WJ, Macdonald IA Apparent improvement in diabetic autonomic neuropathy induced by captopril.JHum Hypertens 1987;1:161-5.
  • Athyros VG, Didangelos TP, Karamitsos DT, Papageorgiou AA, Boudoulas H., Kontopoulos AG Long-term effect of converting enzyme inhibition on circadian sympathetic and parasympathetic modulation in patients with diabetic autonomic neuropathy. Acta Cardiol 1998;53:201-09.[Web of Science][Medline] [Order article via Infotrieve]
  • Salo TM, Viikari JS, Antila KJ, Voipio-Pulkki LM, Jalonen JO, Valimaki IA Antihypertensive treatment and heart rate variability in diabetic patients: role of cardiac autonomic neuropathy. J Auton Nerv Syst 1996;60:61-70.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Malik RA Can diabetic neuropathy be prevented by angiotensin-converting enzyme inhibitors? Ann Med 2000; 32:1-5.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Poulsen PL, Ebbehøj E., Hansen KW, Mogensen CE 24-h blood pressure and autonomic function is related to albumin excretion within the normoalbuminuric range in IDDM patients. Diabetologia 1997;40:718-25.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Poulsen PL, Hansen KW, Ebbehøj E., Knudsen ST, Mogensen CE No deleterious effects of tight blood glucose control on 24-hour ambulatory blood pressure in normoalbuminuric insulin-dependent diabetes mellitus patients. J Clin Endocrinol Metab 2000;85:155-8.[Abstract/Free Full Text]
  • Poulsen PL, Ebbehøj E., Hansen KW, Mogensen CE Effects of smoking on 24-h ambulatory blood pressure and autonomic function in normoalbuminuric insulin-dependent diabetes mellitus patients. Am J Hypertens 1998;11:1093-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Poulsen PL, Bek T., Ebbehøj E., Hansen KW, Mogensen CE 24-h ambulatory blood pressure and retinopathy in normoalbuminuric IDDM patients. Diabetologia 1998;41:105-10.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Poulsen PL, Ebbehøj E., Knudsen S. et al. Increased QTc dispersion is related to blunted circadian blood pressure variation in normoalbuminuric type 1 diabetic patients. Diabetes 2001;50(4):837-42.[Abstract/Free Full Text]

Journal of Renin-Angiotensin-Aldosterone System, Vol. 4, No. 1, 17-26 (2003)
DOI: 10.3317/jraas.2003.002
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