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Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta

Laboratory of Experimental and Applied Physiology of the Romanian Academy Iasi, Romania, ihaulica{at}yahoo.com

Walther Bild

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Christian N Mihaila

Department of Physiology, University of Medicine and Pharmacy Iasi, Romania

Teodor Ionita

Laboratory of Experimental and Applied Physiology of the Romanian Academy Iasi, Romania

Corneliu P Boisteanu

Laboratory of Experimental and Applied Physiology of the Romanian Academy Iasi, Romania

Bogdan Neagu

Laboratory of Experimental and Applied Physiology of the Romanian Academy Iasi, Romania

Using isolated rat aortic rings perfused with Krebs-Henseleit saline, the vascular effects of angiotensin (1-7) (Ang [1-7]) and its interactions with angiotensin II (Ang II) were investigated.

Ang (1-7) induced endothelium-dependent relaxation and vasodilating effects in preparations precontracted with phenylephrine. Without preconstriction, Ang (1-7) at high doses (10 ^-6—10^-5 M) produced either a significant inhibition of Ang IIinduced vasoconstriction or a non-tachyphylactic vasopressor response. While losartan inhibited the vasoconstriction induced by Ang (1-7), A779 blocked only its relaxation. Unlike losartan, blockade of AT₂-receptors with PD 123319 had no effect.

Taking into account the biphasic effects of angiotensin (1-7), we propose that it is one of the active components of the renin-angiotensin system, which is involved as a modulator both in the counter-regulatory actions of Ang II and in the self-regulation of its own vasodilating effects.

Key Words: vascular smooth muscle • angiotensin II • angiotensin (1-7)

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 4, No. 2, 124-128 (2003)
DOI: 10.3317/jraas.2003.013


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