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Regulation of renal proximal fluid uptake by luminal and peritubular angiotensin II

Department of Physiology, Faculty of Science, Prince of Songkla University, Hatyai, Songkla 90112, Thailand, hsiriphu{at}ratree.psu.ac.th

Peter J Harris

Department of Physiology, The University of Melbourne, Victoria 3010, Australia

Introduction

Angiotensin II (Ang II), when administered to either tubular lumen or peritubular capillary, exerts a biphasic action on proximal fluid uptake rate. At low concentrations, (10^-12—10^-10M) Ang II stimulates fluid transport, whereas higher doses (> 10^-9 M) inhibit. Ang II is secreted into the lumen in the proximal tubule and the concentration of Ang II in the proximal lumen has been reported to be in the nanomolar range, 100—1,000 times higher than in peritubular blood. We investigated the regulation of renal proximal fluid transport by luminal (predominantly locally produced) and peritubular capillary (circulatory) Ang II in anaesthetised rats, using a selective AT₁-receptor antagonist, candesartan.

Key Words: Angiotensin II • candesartan • fluid transport • proximal tubule • split-droplet micropuncture

References

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Journal of Renin-Angiotensin-Aldosterone System, Vol. 5, No. 2, 89-92 (2004)
DOI: 10.3317/jraas.2004.016


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hiranyachattada, S. Articles by Harris, P. J Search for Related Content PubMed PubMed Citation Articles by Hiranyachattada, S. Articles by Harris, P. J Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?